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Extracellular matrix
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{{Cleanup|reason=Needs formatting and categories. | date = July 2019}} In biology, the extracellular matrix (ECM) is a three-dimensional network of extracellular macromolecules, such as [[collagen]], [[Enzyme|enzymes]], and glycoproteins, that provide structural and biochemical support of surrounding cells.<ref name="addr">{{cite journal|vauthors=Theocharis AD, Skandalis SS, Gialeli C, Karamanos NK | date = February 2016 | title = Extracellular matrix structure|journal=Advanced Drug Delivery Reviews|volume=97 | pages = 4β27|doi=10.1016/j.addr.2015.11.001|pmid=26562801}}</ref><ref name="bonnans">{{cite journal|vauthors=Bonnans C, Chou J, Werb Z | date = December 2014 | title = Remodelling the extracellular matrix in development and disease|journal=Nature Reviews. Molecular Cell Biology|volume=15|issue=12 | pages = 786β801|doi=10.1038/nrm3904|pmc=4316204|pmid=25415508}}</ref><ref>{{cite journal|vauthors=Michel G, Tonon T, Scornet D, Cock JM, Kloareg B | date = October 2010 | title = The cell wall polysaccharide metabolism of the brown alga Ectocarpus siliculosus. Insights into the evolution of extracellular matrix polysaccharides in Eukaryotes|journal=The New Phytologist|volume=188|issue=1 | pages = 82β97|doi=10.1111/j.1469-8137.2010.03374.x|pmid=20618907}}{{open access}}</ref> Because multicellularity evolved independently in different multicellular lineages, the composition of ECM varies between multicellular structures; however, cell adhesion, cell-to-cell communication and differentiation are common functions of the ECM.<ref>{{cite journal|vauthors=Abedin M, King N | date = December 2010 | title = Diverse evolutionary paths to cell adhesion|journal=Trends in Cell Biology|volume=20|issue=12 | pages = 734β42|doi=10.1016/j.tcb.2010.08.002|pmc=2991404|pmid=20817460}}</ref> == See also == * [[Collagen]] * [[Mast cell]] * [[Matrix metalloproteinase]] ==References== {{Reflist}}
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