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Enteroviral infection hypothesis
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'''The enteroviral hypothesis''' is the hypothesis that a significant subset of patients meeting the criteria for [[myalgic encephalomyelitis]], as well as those affected by the historic [[Epidemic myalgic encephalomyelitis|outbreaks]], had their illness triggered by an [[enterovirus]], one that might continue to persist and contribute to symptoms. It is a hypothesis held by [[John Chia]], [[Byron Hyde]], [[Melvin Ramsay]], and others, and recently investigated by [[Maureen Hanson]].<ref name="Hanson2021"/> ==Theory== Enterovirus symptoms could account for many of the symptoms of [[ME/CFS]].<ref name="Hanson2021"/> {{See also|Enterovirus}} ==Evidence== Rates of enteroviral infection are higher in ME/CFS than in the general population, and a recent review by O'Neal and Hanson (2021) found that a number of outbreaks of myalgic encephalomyelitis/chronic fatigue syndrome were highly likely to have been caused by an [[enterovirus]].<ref name="Hanson2021"/> {{See also|List of enterovirus infection studies}} {{See also|List of myalgic encephalomyelitis and chronic fatigue syndrome outbreaks}} === Trigger === === Persistence === A review by O'Neal and Hanson (2021) found that the presence of chronic enterovirus infection in ME/CFS could not be ruled out.<ref name="Hanson2021"/> ==Notable studies == *2022, The Enterovirus Theory of Disease Etiology in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Critical Review<ref name="Hanson2021">{{Cite journal | title = The Enterovirus Theory of Disease Etiology in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Critical Review | date = 2021 | url=https://www.frontiersin.org/article/10.3389/fmed.2021.688486|journal=Frontiers in Medicine|volume=8|issue= | pages = 688486 | last = O'Neal | first = Adam J. | authorlink = | last2 = Hanson | first2 = Maureen R. | authorlink2 = Maureen Hanson|doi=10.3389/fmed.2021.688486/abstract|pmc=|pmid=|access-date=|issn=2296-858X|quote=|via=}}</ref> - [https://www.frontiersin.org/articles/10.3389/fmed.2021.688486/abstract (Full text)] ==Treatment== ==See also== * [[Persistent infection hypothesis]] * [[Coxsackie B]] * [[Enterovirus]] * [[Non-cytolytic enterovirus]] * [[List of enterovirus infection studies]] * [[Post-mortem brain studies]] ==Learn more== ==References== {{Reflist}} [[Category:Medical hypotheses]]
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