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Dopamine
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==Other conditions== [[Parkinson's disease]] involves the loss of dopaminergic neurons in the midbrain and subsequently reduced dopamine. [[Schizophrenia]], [[ADHD]] and [[restless leg syndrome]] are also associated with altered dopamine. Cerebralspinal iron is decreased in [[restless legs syndrome]] despite normal serum levels.<ref>{{Cite web | url = https://www.hopkinsmedicine.org/neurology_neurosurgery/centers_clinics/restless-legs-syndrome/what-is-rls/causes.html | title = Causes of Restless Legs Syndrome (RLS) {{!}} The Johns Hopkins Center for Restless Legs Syndrome | last = Ciattei | first = Jennifer | website = hopkinsmedicine.org|language=en|access-date=2020-05-28}}</ref> In addition to its neurological effects, reduced dopamine may also have immunological effects in these diseases. Altered dopamine [[metabolism]] may play a role in a number of [[Autoimmune disease|autoimmune diseases]].<ref>{{Cite journal | last = Pacheco | first = Rodrigo | last2 = Contreras | first2 = Francisco | last3 = Zouali | first3 = Moncef| date = 2014 | title = The Dopaminergic System in Autoimmune Diseases |url =https://www.frontiersin.org/articles/10.3389/fimmu.2014.00117/full|journal=Frontiers in Immunology|language=English|volume=5|doi=10.3389/fimmu.2014.00117|issn=1664-3224}}</ref> Dopaminergic neurons are thought to play a role in [[epilepsy|epileptic seizures]] arising from the [[limbic system]].<ref>http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774988/</ref>
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