Anonymous
Not logged in
Talk
Contributions
Create account
Log in
Search
Editing
Dopamine
(section)
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
Namespaces
Page
Discussion
More
More
Page actions
Read
Edit
Edit source
History
Warning:
You are not logged in. Your IP address will be publicly visible if you make any edits. If you
log in
or
create an account
, your edits will be attributed to your username, along with other benefits.
Anti-spam check. Do
not
fill this in!
== Immune system == Dopamine reduces systemic inflammation by blocking [[inflammasome]] activation.<ref>{{Cite journal | last = Yan | first = Yiqing | last2 = Jiang | first2 = Wei | last3 = Liu | first3 = Lei | last4 = Wang | first4 = Xiaqiong | last5 = Ding | first5 = Chen | last6 = Tian | first6 = Zhigang | last7 = Zhou | first7 = Rongbin | date = Jan 2015 | title = Dopamine Controls Systemic Inflammation through Inhibition of NLRP3 Inflammasome | url =http://www.cell.com/cell/abstract/S0092-8674(14)01524-4|journal=Cell|language=English|volume=160|issue=1-2 | pages = 62β73|doi=10.1016/j.cell.2014.11.047|issn=0092-8674|via=}}</ref><ref>{{Cite journal | last = Bordon | first = Yvonne | authorlink = | date = Feb 2015 | title = Dopamine blocks inflammasome activation | url =https://www.nature.com/articles/nri3817|journal=Nature Reviews Immunology|language=en|volume=15|issue=2 | pages = 69β69|doi=10.1038/nri3817|issn=1474-1741|pmc=|pmid=|access-date=|quote=|via=}}</ref> Dopamine has a role in the activity of [[lymphocytes]]. It activates native [[T cell|t cells]] but inhibits the activity of activated t cells.<ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856781/</ref> However, dopamine may also induce the release of [[IL-17|interleukin-17]] in [[rheumatoid arthritis]].<ref>http://www.nature.com/nrd/journal/v10/n4/full/nrd3422.html</ref> Inflammation may also have a role in dopamine production. A study of [[Hepatitis C]] patients found that [[interferon alpha]] treatment resulted in significantly increased levels of [[dihydrobiopterin]] (BH2) and decreased [[tetrahydrobiopterin]] (BH4) as well as reduced conversion of [[phenylalanine]] to [[tyrosine]] in the cerebrospinal fluid, which are associated with decreased dopamine in the brain.<ref>{{Cite web | url = https://pubmed.ncbi.nlm.nih.gov/23072726/ | title = Tyrosine Metabolism During Interferon-Alpha Administration: Association With Fatigue and CSF Dopamine Concentrations | last = Felger | first = JC | authorlink = | last2 = Li | first2 = L | authorlink2 = | date = Jul 2013 | website = Brain, behavior, and immunity|language=en|pmid=23072726| archive-url = | archive-date = |url-status = | access-date=2020-05-28 | last3 = Marvar | first3 = PJ | last4 = Woolwine | first4 = BJ | last5 = Harrison | first5 = DG | last6 = Raison | first6 = CL | last7 = Miller | first7 = AH}}</ref>
Summary:
Please make sure your edits are consistent with
MEpedia's guidelines
.
By saving changes, you agree to the
Terms of use
, and you irrevocably agree to release your contribution under the
CC BY-SA 3.0 License
and the
GFDL
. You agree that a hyperlink or URL is sufficient attribution under the Creative Commons license.
Cancel
Editing help
(opens in new window)
Navigation
Navigation
Skip to content
Main page
Browse
Become an editor
Random page
Popular pages
Abbreviations
Glossary
About MEpedia
Links for editors
Contents
Guidelines
Recent changes
Pages in need
Search
Help
Wiki tools
Wiki tools
Special pages
Page tools
Page tools
User page tools
More
What links here
Related changes
Page information
Page logs