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Dikoma Shungu
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==ME/CFS research== ===Raised lactic acid and lowered glutathone levels in the brain=== In a series of three studies, Prof Shungu found high levels of [[lactic acid]] in ventricular [[cerebrospinal fluid]] and significant correlation between lactic acid levels and the severity of mental fatigue in ME/CFS patients. He later went on to discover levels of the antioxidant [[glutathione]] (GSH) reduced by 36% in brain tissue<ref name="Shungu2012" /> and suggested [[oxidative stress]] was playing a role in ME/CFS. ===Supplementation with N-Acetylcysteine=== At the 2016 IACFS/ME confernce Dr Shungu presented evidence that supplementing patients with [[N-acetylcysteine]] (NAC) raised levels of glutathione in the brains of patients and their symptoms were improved.<ref>{{Cite web | url= http://iacfsme.org/ME-CFS-Primer-Education/News/IACFSME-2016-Program.aspx|url-status=dead|archive-url=https://www.healthrising.org/forums/threads/nac-for-neuroinflammation-in-me-cfs-and-fibromyalgia.5046/post-26022|archive-date=2016-11-21 | title = N-Acetylcysteine Alleviates Cortical Glutathione Deficit and Improves Symptoms in CFS: An In Vivo Validation Study using Proton Magnetic Resonance Spectroscopy | first = N. | last = Weiduschat | first2 = X. | last2 = Mao | first3 =D. | last3 = Vub | first4 = M. | last4 = Blate | first5 = G. | last5 = Kang | first6 = H.S. | last6 = Mangat | first7 = A. | last7 = Artis | first8 = S. | last8 = Banerjee | first9 = G. | last9 = Lange | first10 = C. | last10 = Henchcliff | first11 = B.H. | last11 = Natelson | first12 =D.C. | last12 = Shungu|work=IACFS/ME Syllabus | date = 2016 | page=35}}</ref> In late 2020, Dikoma Shungu registered a randomized clinical trial to determine the effects of [[N-acetylcysteine|NAC]] supplementation on ME/CFS patients with low glutathione levels, especially investigating any change in glutathione levels and oxidative stress.<ref name="NCT04542161">{{Cite web | url = https://clinicaltrials.gov/ct2/show/NCT04542161 | title = Assessment of N-Acetylcysteine as Therapy for Myalgic Encephalomyelitis/Chronic Fatigue Syndrom | last = | first = | authorlink = | date = | website = clinicaltrials.gov|language=en| archive-url = | archive-date = |url-status = | access-date=2020-09-11}}</ref>
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