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Diamine oxidase
(section)
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==Supplementation== DAO food supplements are taken for histamine intolerance in patients with low DAO, for example the supplement DAOsin.<ref name="Schnedl2019">{{Cite journal | last = Schnedl|first = Wolfgang J. | authorlink = | last2 = Schenk | first2 = Michael | authorlink2 = | last3 = Lackner | first3 = Sonja | authorlink3 = | last4 = Enko | first4 = Dietmar | authorlink4 = | last5 = Mangge | first5 = Harald | author-link5 = | last6 = Forster | first6 = Florian | author-link6 = | date = Dec 2019 | title = Diamine oxidase supplementation improves symptoms in patients with histamine intolerance | url =https://pubmed.ncbi.nlm.nih.gov/31807350/|journal=Food Science and Biotechnology|volume=28|issue=6 | pages = 1779–1784|doi=10.1007/s10068-019-00627-3|issn=2092-6456|pmc=6859183|pmid=31807350|access-date=|quote=|via=}}</ref><ref name="DAOsin2019">{{Cite web | last = Sciotec Diagnostic Technologies GmbH|first = | authorlink = | date = 2018-04-16 | title = Pilotstudie Zur Untersuchung Der Wirkung Einer Oralen Supplementation Von Diaminooxidase (DAOsin®) Bei Histamin-Intoleranz in Bezug Auf Die Steigerung Der Erniedrigten Endogenen Diaminooxidase-Aktivität|website=clinicaltrials.gov | url = https://clinicaltrials.gov/ct2/show/NCT03298568|language=de|volume=|issue= | pages = |doi=|pmc=|pmid=|access-date=|quote=|via=}}</ref> DAO food supplements form are sometimes taken by individuals with [[mast cell activation disorder]].{{citation needed}} In rats, [[Magnesium]] is an important cofactor in the production of DAO and magnesium deficiency may result in decreased DAO activity and excess histamine levels.<ref name="magrats1987">{{Cite journal| issn = 0272-3530| volume = 5 | issue = 2| pages = 89–96| last1 = Nishio | first1 = A. | last2 = Ishiguro | first2 = S. | last3 = Miyao | first3 = N.| title = Specific change of histamine metabolism in acute magnesium-deficient young rats| journal = Drug-Nutrient Interactions| date = 1987 | pmid = 3111814 | url = https://www.ncbi.nlm.nih.gov/pubmed/3111814}}</ref> [[Copper]], [[Vitamin B6]]<ref name="b6pregnant1986">{{Cite journal| issn = 0002-9165| volume = 44 | issue = 6| pages = 907–913| last1 = Martner-Hewes | first1 = P.M. | last2 = Hunt | first2 = I.F. | last3 = Murphy | first3 = N.J. | last4 = Swendseid | first4 = M.E. | last5 = Settlage | first5 = R.H. | title = Vitamin B-6 nutriture and plasma diamine oxidase activity in pregnant Hispanic teenagers.| journal = The American Journal of Clinical Nutrition | date = 1986-12-01| url = http://ajcn.nutrition.org/content/44/6/907 | pmid = 3098085 | authorlink = |chapter=|edition=|isbn=}}</ref> and [[Vitamin C]] are other important DAO cofactors. [[Heparin]] increases the activity of DAO in the [[blood]].<ref name="heparindvt2004">{{Cite journal| doi = 10.1016/j.vph.2004.02.002| issn = 1537-1891| volume = 40 | issue = 6| pages = 293–300| last1 = Klocker | first1 = Josef | last2 = Perkmann | first2 = Reinhold | last3 = Klein-Weigel | first3 = Peter | last4 = Mörsdorf | first4 = Gabriele | last5 = Drasche | first5 = Astrid | last6 = Klingler | first6 = Anton | last7 = Fraedrich | first7 = Gustav | last8 = Schwelberger | first8 = Hubert G.| title = Continuous administration of heparin in patients with deep vein thrombosis can increase plasma levels of diamine oxidase| journal = Vascular Pharmacology | date = January 2004 | pmid = 15063833}}</ref>
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