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==References== <references> <ref name="Aoki, 2016">{{Citation | last1 = Aoki | first1 = R | author-link1 = | last2 = Kobayashi | first2 = N | authorlink2 = | last3 = Suzuki | first3 = G | authorlink3 = | last4 = Kuratsune | first4 = H | authorlink4 = | last5 = Shimada | first5 = K | author-link5 = | last6 = Oka | first6 = N | author-link6 = | last7 = Takahashi | first7 = M | author-link7 = | last8 = Yamadera | first8 = W | author-link8 = | last9 =Iwashita | first9 = M | author-link9 = | last10 =Tokuno | first10 = S | author-link10 = | last11= Nibuya | first11 = M | author-link11 = | last12= Tanichi | first12 = M | author-link12 = | last13= Mukai | first13 = Y | author-link13 = | last14= Mitani | first14 = K | author-link14 = | last15= Kondo | first15 = K | author-link15 = | last16= Ito | first16 = H | author-link16 = | last17= Nakayama | first17 = K | author-link17 = | title = Human herpesvirus 6 and 7 are biomarkers for fatigue, which distinguish between physiological fatigue and pathological fatigue | journal =Biochemical and Biophysical Research Communications | volume = 478 | issue = 1 | pages = 424-30 | date = 2016 | pmid = 27396623 | doi = 10.1016/j.bbrc.2016.07.010 }}</ref> <ref name="Armstrong, 2015">{{Cite journal | last1 = Armstrong | first1 = Christopher W. | author-link1 = Christopher Armstrong | last2 = McGregor | first2 = Neil R. | authorlink2 = Neil McGregor | last3 = Lewis | first3 = Donald P. | authorlink3 = Donald Lewis | last4 = Butt | first4 = Henry L. | authorlink4 = Henry Butt | last5 = Gooley | first5 = Paul R. | author-link5 = Paul R. 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Staines | last7 = Marshall-Gradisnik | first7 = S | author-link8 = Sonya Marshall-Gradisnik | title = Pilot Study of Natural Killer Cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Multiple Sclerosis | journal =Scand J Immunol | date = Jan 2016 | volume = 83 | issue = 1 | pages = 44-51 | pmid = 26381393 | doi = 10.1111/sji.12388 | url = https://www.ncbi.nlm.nih.gov/pubmed/26381393 }}</ref> <ref name="IOM2015MECFS">{{citation | last1 = Institute of Medicine (USA) | last2 = Committee on the Diagnostic Criteria for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome | title = Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness | date = February 10, 2015 | url = http://iom.nationalacademies.org/Reports/2015/ME-CFS.aspx }}</ref> <ref name="Klimas, 2012">{{Citation | last1 = Klimas | first1 = NG | author-link1 = Nancy Klimas | last2 = Broderick | first2 = G | authorlink2 = Gordon Broderick | last3 = Fletcher | first3 = MA | authorlink3 = Mary Ann 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Lorne J. | authorlink4 = | last5 = Houghton | first5 = Michael | author-link5 = Michael Houghton | title = Reductions in circulating levels of IL-16, IL-7 and VEGF-A in myalgic encephalomyelitis/chronic fatigue syndrome | journal = Cytokine | volume = 78 | issue = | pages = 27-36 | date = 2016 | pmid = 26615570 | doi = 10.1016/j.cyto.2015.11.018 }}</ref> <ref name="Lerner, 2012">{{Citation | last1 = Lerner | first1 = AM | author-link1 = A Martin Lerner | last2 = Ariza | first2 = ME | authorlink2 = | last3 = Williams | first3 = M | authorlink3 = | last4 = Jason | first4 = L | authorlink4 = Leonard Jason | last5 = Beqaj | first5 = S | author-link5 = | last6 = Fitzgerald | first6 = JT | author-link6 = | last7 = Lemeshow | first7 = S | author-link7 = | last8 = Glaser | first8 = R | author-link8 = Ronald Glaser | title = Antibody to Epstein-Barr Virus Deoxyuridine Triphosphate Nucleotidohydrolase and Deoxyribonucleotide Polymerase in a Chronic Fatigue Syndrome Subset | journal = PLoS ONE | volume = 7 | issue = 11 | page = e47891 | date = 2012 | pmid = | doi = 10.1371/journal.pone.0047891 }}</ref> <ref name="Loebel, 2016">{{Citation | last1 = Loebel | first1 = M | author-link1 = | last2 = Grabowski | first2 = P | authorlink2 = | last3 = Heidecke | first3 = H | authorlink3 = | last4 = Bauer | first4 = S | authorlink4 = | last5 = Hanitsch | first5 = LG | author-link5 = | last6 = Wittke | first6 = K | author-link6 = | last7 = Meisel | first7 = C | author-link7 = | last8 = Reinke | first8 = P | author-link8 = | last9 = Volk | first9 = H | author-link9 = | last10 = Fluge | first10 = Ø | author-link10 = Øystein Fluge | last11 = Mella | first11 = O | author-link11 = Olav Mella | last12 = Scheibenbogen | first12 = C | author-link12 = Carmen Scheibenbogen | title = Antibodies to β adrenergic and muscarinic cholinergic receptors in patients with Chronic Fatigue Syndrome | journal =Brain, behavior, and immunity | volume = 52 | issue = | pages = 32-39 | date = 2016 | doi = 10.1016/j.bbi.2015.09.013 }}</ref> <ref name="Moneghetti, 2018">{{Cite journal | last1 = Moneghetti | first1 = Kegan J. | author-link1 = | last2 = Skhiri | first2 = Mehdi | authorlink2 = | last3 = Contrepois | first3 = Kévin | authorlink3 = | last4 = Kobayashi | first4 = Yukari | authorlink4 = | last5 = Maecker | first5 = Holden T. | author-link5 = | last6 = Davis | first6 = Mark M. | author-link6 = Mark Davis | last7 = Snyder | first7 = Michael | author-link7 = | last8 = Haddad | first8 = Francois | author-link8 = | last9 =Montoya | first9 = Jose G. | author-link9 = Jose Montoya | title = Value of Circulating Cytokine Profiling During Submaximal Exercise Testing in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome | journal =Scientific Reports | volume = 8 | issue = | pages = | date = 2018 | pmid = | doi = 10.1038/s41598-018-20941-w }}</ref> <ref name="Montoya, 2017">{{citation | last1 = Montoya | first1 = Jose G. | author-link1 = Jose Montoya | last2 = Holmes | first2 = Tyson H. | authorlink2 = | last3 = Anderson | first3 = Jill N. | authorlink3 = | last4 = Maecker | first4 = Holden T. | authorlink4 = | last5 = Rosenberg-Hasson | first5 = Yael | author-link5 = | last6 = Valencia | first6 = Ian J. | author-link6 = Ian Valencia | last7 = Chu | first7 = Lily | author-link8 = Lily Chu | last8 = Younger | first8 = Jarred W. | author-link8 = Jarred Younger | last9 =Tato | first9 = Cristina M. | author-link9 = | last10 = Davis | first10 = Mark M. | author-link10 = Mark Davis | title = Cytokine signature associated with disease severity in chronic fatigue syndrome patients | journal =Proceedings of the National Academy of Sciences of the United States of America | volume = 114 | issue = 34 | pages = E7150-E7158 | date = 2017 | pmid = | doi = 10.1073/pnas.1710519114 }}</ref> <ref name="Morris, Mar2014">{{Citation | last1 = Morris | first1 =Gerwyn | author-link1 = Gerwyn Morris | last2 = Maes | first2 = Michael | authorlink2 = Michael Maes | title = Oxidative and Nitrosative Stress and Immune-Inflammatory Pathways in Patients with Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS) | journal =Current Neuropharmacology | volume = 12 | issue = 2 | pages = 168–185 | date = 2014| doi = 10.2174/1570159X11666131120224653}}</ref> <ref name="Naviaux, 2016">{{Citation | last1 = Naviaux | first1 = Robert K | author-link1 = Robert Naviaux | last2 = Naviaux | first2 = Jane C. | authorlink2 = | last3 = Lia | first3 = Kefeng | authorlink3 = | last4 = Bright | first4 = A. 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| authorlink3 = | last4 = Newton | first4 = Julia | authorlink4 = Julia Newton | title = Shortened QTc interval in chronic fatigue syndrome | journal = Bulletin of IACFS/ME | volume = 19 | issue = 3/4 | pages = 202-211 | date = 2012 | url = https://iacfsme.org/portals/0/pdf/Summer2012-Newton-Report-202-211.pdf}}</ref> <ref name="Sakudo, 2016">{{Cite journal | last1 = Sakudo | first1 = A. | author-link1 = | title = Potential use of visible and near-infrared spectroscopy for the analysis and diagnosis of chronic fatigue syndrome (Review)| journal = Molecular Medicine Reports | volume = 14 | issue = 3| pages = 1875-1879 | date = 2016 | doi = 10.3892/mmr.2016.5476}}</ref> <ref name="Sakudo, 2012">{{Cite journal | last1 = Sakudo | first1 = A. | author-link1 = | last2 = Kuratsune | first2 = H. | authorlink2 = | last3 = Kato | first3 = YH. | authorlink3 = | last4 = Ikuta | first4 = K. | authorlink4 = | title = Visible and near-infrared spectra collected from the thumbs of patients with 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