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Diagnostic biomarker
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===Blood and fecal matter=== In 2016 gut [[microbiome]] study done by [[Ludovic Giloteaux|Giloteaux]], [[Maureen Hanson | Hanson]], et. al., the gut bacterial [[microbiome]] of 48 [[ME/CFS]] patients and 39 healthy controls was examined by sequencing regions of 16S [[ribosomal ribonucleic acid]] (rRNA) genes that allow identification of the different types of bacteria present in the stool as well as [[inflammatory markers]] from serum. "Bacterial diversity was decreased in the ME/CFS specimens compared to controls, in particular, a reduction in the relative abundance and diversity of members belonging to the [[Firmicutes phylum]]...Using a machine learning approach trained on the data obtained from [[16S rRNA]] and inflammatory markers, individuals were classified correctly as ME/CFS with a cross-validation accuracy of 82.93%."<ref name="Giloteaux, 2016" />
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