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Diagnostic biomarker
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===Blood and muscle nerves (electrical)=== A combination of M-wave, TBars, and CD26 values has been proposed as a possible diagnostic marker. A 2016 study in [[France]] by [[Fenouillet]], et al, examined 36 ME/CFS cases and 11 healthy controls with regard to three biological variables: a) post-exercise [[M-wave]] - a measurement after electrical stimulation of muscle nerves which coordinates with [[Muscle fatigability|muscle fatigue]] b) [[TBARS]] variations - a plasma marker which represents excessive oxidative stress response to exercise, and c) [[CD26]]-expression at rest - a protein potentially related to [[inflammation]], which was found to decrease in CFS patients. Although the researchers set out to explore physiological and biological abnormalities that could be indicative of the etiology, "striking differences" in the results between patients and controls lead them to believe that this combination could be used to identify patients with ME/CFS and help to distinguish ME/CFS patients from [[fibromyalgia]] patients.<ref name="Fenouillet, 2016" /> Obstacle for use: The findings in this published study need to be validated through replication by other studies.
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