Anonymous
Not logged in
Talk
Contributions
Create account
Log in
Search
Editing
Diagnostic biomarker
(section)
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
Namespaces
Page
Discussion
More
More
Page actions
Read
Edit
Edit source
History
Warning:
You are not logged in. Your IP address will be publicly visible if you make any edits. If you
log in
or
create an account
, your edits will be attributed to your username, along with other benefits.
Anti-spam check. Do
not
fill this in!
===Metabolomics=== ''{{main article| page_name =Metabolomics}}'' [[Robert Naviaux |Naviaux]], et al, at the University of California, San Diego School of Medicine reported in 2016 "that targeted, broad-spectrum [[metabolomics]] of plasma not only revealed a characteristic chemical signature but also revealed an unexpected underlying biology." The researchers found that CFS patients had an average of 40 metabolic abnormalities. From these, a set of 8 metabolites were identified in male patients and a set of 13 metabolites in females that performed well together as a diagnostic test. Both sets gave a 95% Confidence Interval. The eight metabolites selected for males were [[phosphatidyl choline PC]](16:0/16:0), [[glucosylceramide GC]](18:1/16:0), [[1-P5C]], [[FAD]], [[pyroglutamic acid]] (also known as [[5-oxoproline]]), [[2-hydroxyisocaproic acid]] (HICA), [[serine|l-serine]], and [[lathosterol]]. The 13 metabolites selected for females were [[THC]](18:1/24:0), phosphatidyl choline PC(16:0/16:0), [[hydroxyproline]], [[ceramide]](d18:1/22:2), [[lathosterol]], [[Adenosine triphosphate|adenosine]], [[phosphatidylinositol PI]](16:0/16:0), FAD, 2-octenoylcarnitine, [[phosphatidyl choline plasmalogen PC]](22:6/P18:0), phosphatidyl choline PC(18:1/22:6), 1-P5C, and [[CDCA]]. There are several metabolites that appear on both the males and female lists.<ref name="Naviaux, 2016" /> Obstacle for use: The specialized laboratory equipment needed for this test is usually only available in facilities engaged in research.
Summary:
Please make sure your edits are consistent with
MEpedia's guidelines
.
By saving changes, you agree to the
Terms of use
, and you irrevocably agree to release your contribution under the
CC BY-SA 3.0 License
and the
GFDL
. You agree that a hyperlink or URL is sufficient attribution under the Creative Commons license.
Cancel
Editing help
(opens in new window)
Navigation
Navigation
Skip to content
Main page
Browse
Become an editor
Random page
Popular pages
Abbreviations
Glossary
About MEpedia
Links for editors
Contents
Guidelines
Recent changes
Pages in need
Search
Help
Wiki tools
Wiki tools
Special pages
Page tools
Page tools
User page tools
More
What links here
Related changes
Page information
Page logs