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Derya Unutmaz
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[[File:Derya Unutmaz.png|200px|thumb|right|Source: The Jackson Labs]] '''Derya Unutmaz''', MD, is a professor of Immunology at The Jackson Laboratory for Genomic Medicine and the Principal Investigator for [[Jackson Laboratory ME/CFS Collaborative Research Center]], Farmington, Connecticut, US.<ref>{{Cite web | url = https://www.jax.org/research-and-faculty/research-labs/the-unutmaz-lab | title = The Unutmaz Lab|website=The Jackson Laboratory|language=en|access-date=2019-04-05}}</ref> ==Education and training== The Turkish-born Unutmaz earned his medical degree at Marmara University Medical School in Istanbul.<ref>https://www.linkedin.com/in/deryaunutmaz</ref> He completed postdoctoral appointments in the immunology department of Novartis in Basel, [[Switzerland]]; the Immunobiology Research Institute of Novartis and Chiron Corporation in Siena, Italy; and the Skirball Institute of New York University. == Career == He joined the Vanderbilt University School of Medicine faculty in 1999 as assistant professor of microbiology and immunology, rising to associate professor. In 2006 he moved to the New York University School of Medicine as an associate professor of microbiology, later adding appointments to the departments of medicine and pathology. Before he joined The Jackson Laboratory, he worked at the New York University School of Medicine in Manhattan, where he was professor of microbiology, pathology and medicine.<ref>https://www.linkedin.com/in/deryaunutmaz?authType=NAME_SEARCH&authToken=40bz&locale=en_US&srchid=1653593721481246506435&srchindex=1&srchtotal=1&trk=vsrp_people_res_photo&trkInfo=VSRPsearchId%3A1653593721481246506435%2CVSRPtargetId%3A19403520%2CVSRPcmpt%3Aprimary%2CVSRPnm%3Atrue%2CauthType%3ANAME_SEARCH</ref> The author of 104 research papers,<ref>{{Cite web | url = https://www.ncbi.nlm.nih.gov/myncbi/browse/collection/46030678/?sort=date&direction=ascending | title = My Bibliography - My NCBI Collection | website = ncbi.nlm.nih.gov|access-date=2019-04-05}}</ref> Unutmaz has contributed to seven awarded and pending patents.<ref>{{Cite web | url = https://www.google.com/search?tbo=p&tbm=pts&hl=en&q=ininventor:%22Derya+Unutmaz%22 | title = ininventor:"Derya Unutmaz" - Google Search | website = google.com|access-date=2019-04-05}}</ref> ==Research background== Unutmaz has done extensive work in studying the molecular mechanisms of [[T cell]]s and their involvement in [[HIV]] infection and other chronic inflammatory diseases in humans. “My research has focused on understanding what HIV ‘knows’ about the immune system and how HIV infection leads to disease. We are now using the knowledge we acquired from studying HIV to other chronic inflammatory disorders and to understand the aging of the immune system. JAX [The Jackson Laboratory] will be an ideal institution to continue our studies at the genomics level and translate them for clinical use.”<ref>{{Cite web | url = https://www.jax.org/news-and-insights/2014/november/immunologist-hiv-expert-derya-unutmaz-m-d-joins-jackson-laboratory-faculty | title = Immunologist, HIV expert Derya Unutmaz, M.D., joins Jackson Laboratory faculty | last = Peterson | first = Joyce|website=The Jackson Laboratory|language=en|access-date=2019-04-05}}</ref> His laboratory’s discoveries include the role of [[cytokine]]s (proteins produced by immune cells) in making [[CD4+]] T cells more vulnerable to HIV infection; and how HIV preferentially infects and perturbs human [[T cell]] subsets, including NKT, regulatory T (Tregs) and [[interleukin 17|IL-17]]-secreting (Th17) cells. ==ME/CFS research== In June of 2016, Unutmaz received five years of funding — totaling $3,281,515 from the National Institute of Allergy and Infectious Diseases — to find better ways to diagnose and treat [[ME/CFS]]. Unumatz will screen blood samples for potential immunological biomarkers of the disease, and using the results to develop better diagnostic tools and personalized treatments. His work will focus on [https://en.wikipedia.org/wiki/Long_non-coding_RNA Long non-coding RNA].<ref>{{Cite web | url = https://www.jax.org/news-and-insights/2016/june/unutmaz-receives-federal-grant-for-chronic-fatigue-research | title = $3.3 million federal grant to fund JAX chronic fatigue syndrome research | last = Peterson | first = Joyce|website=The Jackson Laboratory|language=en|access-date=2019-04-05}}</ref><ref>{{Cite web | url = http://www.eurekalert.org/pub_releases/2016-06/jl-nft060716.php | title = NIAID funding to Jackson Laboratory researcher to investigate chronic fatigue syndrome|website=EurekAlert!|language=en|access-date=2019-04-05}}</ref> In 2017, Unutmaz and his lab was awarded a five-year grant totaling $10,553,732<ref>{{Cite web | url = https://www.jax.org/news-and-insights/2017/september/new-chronic-fatigue-center-grant | title = NIH awards $10.6M research center grant to The Jackson Laboratory for study of chronic fatigue syndrome | last = Peterson | first = Joyce Dall'Acqua|website=The Jackson Laboratory|language=en|access-date=2019-04-05}}</ref> from the [[National Institutes of Health]] for one of the country's first Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Collaborative Research Centers (CRC). This CRC will work in conjunction with Drs. [[Lucinda Bateman]] and [[Suzanne Vernon]] at the [[Bateman Horne Center]] of Salt Lake City, Utah; Dr. Xudong Yao at the University of Connecticut; Dr. Alison Motsinger-Reif at North Carolina State University and Precise.ly, a San Francisco-based company.<ref>{{Cite web | url = https://www.nih.gov/news-events/news-releases/nih-announces-centers-myalgic-encephalomyelitis-chronic-fatigue-syndrome-research | title = NIH announces centers for myalgic encephalomyelitis/chronic fatigue syndrome research | date = 2017-09-27 | website = National Institutes of Health (NIH)|language=EN|access-date=2019-04-05}}</ref> The CRC's focus will be on the topological mapping of immune, microbiota, metabolomic and clinical phenotypes in ME/CFS.<ref>{{Cite web | url = https://projectreporter.nih.gov/project_info_description.cfm?aid=9479803&icde=36166814&ddparam=&ddvalue=&ddsub=&cr=3&csb=default&cs=ASC&pball= | title = Project Information - NIH RePORTER - NIH Research Portfolio Online Reporting Tools Expenditures and Results|website=projectreporter.nih.gov|access-date=2019-04-05}}</ref> ==Research studies== * 2019, Perturbation of effector and regulatory [[T cell]] subsets in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)<ref>{{Cite journal | last = Karhan | first = Ece | last2 = Gunter | first2 = Courtney L | last3 = Ravanmehr | first3 = Vida | last4 = Horne | first4 = Meghan | last5 = Kozhaya | first5 = Lina | last6 = Renzullo | first6 = Stephanie | last7 = Placek | first7 = Lindsey | last8 = George | first8 = Joshy | last9 = Robinson | first9 = Peter N | last10 = Vernon | first10 = Suzanne D. | author-link10 = Suzanne Vernon | last11 = Bateman | first11 = Lucinda | author-link11 = Lucinda Bateman | last12 = Unutmaz | first12 = Derya | author-link12 = | date = 2019-12-26 | title = Perturbation of effector and regulatory T cell subsets in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)|journal=Biorxiv | url = http://biorxiv.org/lookup/doi/10.1101/2019.12.23.887505|language=en|doi=10.1101/2019.12.23.887505}}</ref> - [https://www.biorxiv.org/content/10.1101/2019.12.23.887505v1.full (Full text)] *2020, Hemodynamics during the 10-minute NASA Lean Test: evidence of circulatory decompensation in a subset of ME/CFS patients<ref>{{Cite journal | last = Lee | first = Jihyun | authorlink = | last2 = Vernon | first2 = SuzanneD. | authorlink2 = Suzanne Vernon | last3 = Jeys | first3 = Patricia | authorlink3 = | last4 = Ali | first4 = Weam | authorlink4 = | last5 = Campos | first5 = Andrea | author-link5 = | last6 = Unutmaz | first6 = Derya | author-link6 = Derya Unutmaz | last7 = Yellman | first7 = Brayden | last8 = Bateman | first8 = Lucinda | author-link8 = Lucinda Bateman | date = Dec 2020 | title = Hemodynamics during the 10-minute NASA Lean Test: evidence of circulatory decompensation in a subset of ME/CFS patients |url =https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-020-02481-y|journal=Journal of Translational Medicine|language=en|volume=18|issue=1 | pages = 314|doi=10.1186/s12967-020-02481-y|issn=1479-5876|pmc=7429890|pmid=32799889|access-date=|quote=|via=}}</ref> - [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429890/ (Full text)] ==Talks and interviews== *19 Jul 2018, [https://www.youtube.com/watch?v=dFCSA9E5Ds8 ''Crossroad of the immune response and the microbiome: Impact on ME/CFS''] Webinar sponsored by [[Solve ME/CFS Initiative]] *23 Oct 2021, [https://youtu.be/2xVWU9TvAmU Metabolic and Immunological Perturbations During ME/CFS], given at the [[Massachusetts ME/CFS & FM Association]] 2021 annual meeting ==Online presence== *[https://twitter.com/derya_ Twitter] ==See also== *[[Immune system]] ==Learn more== *12 Jan 2018, [https://jaxmecfs.com/2018/01/12/january-2018-spotlight-interview-with-derya-unutmaz/ Scientist Spotlight: Derya Unutmaz, M.D.] *5 Jul 2016, [http://www.courant.com/business/hc-jackson-lab-chronic-fatigue-20160705-story.html Jackson Laboratory Researchers Looking Into Chronic Fatigue Syndrome] *7 Jun 2016, [https://www.eurekalert.org/pub_releases/2016-06/jl-nft060716.php NIAID funding to Jackson Laboratory researcher to investigate chronic fatigue syndrome] ==References== {{reflist}} [[Category:Researchers]] [[Category:US researchers]]
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