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Deconditioning
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== Notable studies == *1992, Skeletal muscle metabolism in the chronic fatigue syndrome. In vivo assessment by 31P nuclear magnetic resonance spectroscopy<ref name="Wong1992">{{Cite journal | last = Wong|first = R. | authorlink = | last2 = Lopaschuk | first2 = G. | authorlink2 = | last3 = Zhu | first3 = G. | author-link3 = | last4 = Walker | first4 =D. | author-link4 = | last5 = Catellier | first5 =D. | author-link5 = | last6 = Burton | first6 =D. | last7 = Teo | first7 = K. | last8 = Collins-Nakai | first8 = R. | last9 = Montague | first9 = T. | date = Dec 1992 | title = Skeletal muscle metabolism in the chronic fatigue syndrome. In vivo assessment by 31P nuclear magnetic resonance spectroscopy | url = https://www.ncbi.nlm.nih.gov/pubmed/1446478|journal=Chest|volume=102|issue=6 | pages = 1716β1722|issn=0012-3692|pmid=1446478|quote=|via= | author-link6 = | author-link8 = | author-link8 = | author-link9 = }}</ref> *2001 - [https://www.tandfonline.com/doi/abs/10.3109/09638288.2010.541543 Is physical deconditioning a perpetuating factor in chronic fatigue syndrome? A controlled study on maximal exercise performance and relations with fatigue, impairment and physical activity?]<ref name="Bazelmans2001">{{Cite journal | last = Bazelmans | first = Ellen | last2 = Bleijenberg | first2 = Gijs | last3 = Van Der Meer | first3 = Jos W. | last4 = Folgering | first4 = Hans | date = Jan 2001 | title = Is physical deconditioning a perpetuating factor in chronic fatigue syndrome? A controlled study on maximal exercise performance and relations with fatigue, impairment and physical activity | url = https://www.ncbi.nlm.nih.gov/m/pubmed/11200949/|journal=Psychological Medicine|volume=31|issue=1 | pages = 107β114|issn=0033-2917|pmid=11200949|via=|quote= | authorlink = Ellen Bazelmans | authorlink2 = Gijs Bleijenberg | authorlink3 = Jos van der Meer | author-link4 = Hans Folgering | author-link5 = }}</ref> *2010 - [https://www.researchgate.net/profile/Mark_Van_Ness/publication/41121299_Postexertional_Malaise_in_Women_with_Chronic_Fatigue_Syndrome/links/00b49521532730549e000000/Postexertional-Malaise-in-Women-with-Chronic-Fatigue-Syndrome.pdf Postexertional Malaise in Women with Chronic Fatigue Syndrome]<ref name="VanNess2010">{{Cite journal | last = VanNess | first = J. Mark | authorlink = Mark VanNess | last2 = Stevens | first2 = Staci R. | authorlink2 = Staci Stevens | last3 = Bateman | first3 = Lucinda | authorlink3 = Lucinda Bateman | last4 = Stiles | first4 = Travis L. | author-link4 = Travis Stiles | last5 = Snell | first5 = Christopher R. | author-link5 = Christopher Snell | date = Feb 2010 | title = Postexertional Malaise in Women with Chronic Fatigue Syndrome | url = https://www.researchgate.net/profile/Mark_Van_Ness/publication/41121299_Postexertional_Malaise_in_Women_with_Chronic_Fatigue_Syndrome/links/00b49521532730549e000000/Postexertional-Malaise-in-Women-with-Chronic-Fatigue-Syndrome.pdf | journal=Journal of Women's Health|language=en|volume=19|issue=2 | pages = 239β244|doi=10.1089/jwh.2009.1507|issn=1540-9996|quote=|via=}}</ref> *2011 - [http://emerge.org.au/wp-content/uploads/2014/11/Nijs-J.-et-al.-Tired-of-being-inactive.-Disabil-Rehabil-2011-3317-18.1493-1500.pdf Tired of being inactive: a systematic literature review of physical activity, physiological exercise capacity and muscle strength in patients with chronic fatigue syndrome]<ref name="Nijs2011">{{Cite journal | last = Nijs | first = Jo | authorlink = Jo Nijs | last2 = Aelbrecht | first2 = Senne | authorlink2 = Senne Aelbrecht | last3 = Meeus | first3 = Mira | last4 = Van Oosterwijck | first4 = Jessica | last5 = Zinzen | first5 = Evert | last6 = Clarys | first6 = Peter | date = Jan 2011 | title = Tired of being inactive: a systematic literature review of physical activity, physiological exercise capacity and muscle strength in patients with chronic fatigue syndrome | url = http://emerge.org.au/wp-content/uploads/2014/11/Nijs-J.-et-al.-Tired-of-being-inactive.-Disabil-Rehabil-2011-3317-18.1493-1500.pdf | journal=Disability and Rehabilitation|language=en|volume=33|issue=17-18 | pages = 1493β1500|doi=10.3109/09638288.2010.541543|issn=0963-8288|via=|quote= | authorlink3 = Mira Meeus | author-link4 = Jessica Van Oosterwijck | author-link5 = Evert Zinzen | author-link6 = Peter Clarys}}</ref> *2014, Altered immune response to exercise in patients with chronic fatigue syndrome/myalgic encephalomyelitis: A systematic literature review<ref name="Nijs2014">https://pubmed.ncbi.nlm.nih.gov/24974723/</ref> [https://doc.anet.be/docman/docman.phtml?file=.irua.338b0c.9322.pdf (Full text)] *2014, Neuroinflammation in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: An 11C-(R)-PK11195 PET Study <ref name="Nakatomi2014">https://doi.org/10.2967/jnumed.113.131045</ref> - [https://doi.org/10.2967/jnumed.113.131045 (Full text)] *2016 - Unexplained exertional dyspnea caused by low ventricular filling pressures: results from clinical invasive cardiopulmonary exercise testing<ref name="Oldham2016">{{Cite journal | last = Oldham|first = William M. | authorlink = William Oldham | last2 = Lewis | first2 = Gregory D. | authorlink2 = Gregory Lewis | last3 = Opotowsky | first3 = Alexander R. | author-link3 = Alexander Opotowsky | last4 = Waxman | first4 = Aaron B. | author-link4 = Aaron Waxman | last5 = Systrom | first5 = David M. | author-link5 = David Systrom | date = March 2016 | title = Unexplained Exertional Dyspnea Caused by Low Ventricular Filling Pressures: Results from Clinical Invasive Cardiopulmonary Exercise Testing | url =http://www.journals.uchicago.edu/doi/pdfplus/10.1086/685054|journal=Pulmonary Circulation|language=en|volume=6|issue=1 | pages = 55β62|doi=10.1086/685054|issn=2045-8932|pmc=4860548|pmid=27162614|via=}}</ref> :* [[Cort Johnson]] breaks down the study in [[Health Rising]] article ''The Exercise Intolerance in POTS, ME/CFS and Fibromyalgia Explained?''<ref name=":0" /> Article Heading: "Not Deconditioning" :<blockquote>The study also indicated neither deconditioning or a reduced maximal effort, both of which have been suspected in ME/CFS, play a role in the exercise intolerance found. In fact, deconditioned people, ironically, exhibit an opposite finding (increased as opposed to decreased filling pressures) to that found in this study.<ref name=":0">{{Cite news |url = http://www.healthrising.org/blog/2016/07/04/exercise-intolerance-fibromyalgia-chronic-fatigue-pots-explained/ | title = The Exercise Intolerance in POTS, ME/CFS and Fibromyalgia Explained? - Health Rising | last = Johnson | first = Cort | date = 2016-07-04|work=Health Rising|access-date=2018-10-23| archive-url = | archive-date = |url-status = | language=en-US|quote= | authorlink = Cort Johnson}}</ref></blockquote> * 2018 - [https://www.gavinpublishers.com/articles/Research-Article/Journal-of-Thrombosis-and-Circulation/The-Abnormal-Cardiac-Index-and-Stroke-Volume-Index-Changes-During-a-Normal-Tilt-Table-Test-in-ME-CFS-Patients-Compared-to-Healthy-Volunteers-are-Not-Related-to-Deconditioning The Abnormal Cardiac Index and Stroke Volume Index Changes During a Normal Tilt Table Test in ME/CFS Patients Compared to Healthy Volunteers, are Not Related to Deconditioning]<ref name="vanCampen2018">{{Cite journal | last = van Campen | first = CMC | authorlink = Linda van Campen | last2 = Visser | first2 = FC | authorlink2 = Frans Visser | date = 2018 | title = The Abnormal Cardiac Index and Stroke Volume Index Changes During a Normal Tilt Table Test in ME/CFS Patients Compared to Healthy Volunteers, are Not Related to Deconditioning | url =https://www.gavinpublishers.com/articles/Research-Article/Journal-of-Thrombosis-and-Circulation/The-Abnormal-Cardiac-Index-and-Stroke-Volume-Index-Changes-During-a-Normal-Tilt-Table-Test-in-ME-CFS-Patients-Compared-to-Healthy-Volunteers-are-Not-Related-to-Deconditioning|journal=Journal of Thrombosis and Circulation|volume=|issue= | pages = |doi=10.29011/JTC-107.000007|via=|quote=}}</ref> *2021, Deconditioning does not explain orthostatic intolerance in ME/CFS (myalgic encephalomyelitis/chronic fatigue syndrome)<ref name="vanCampen2021">https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-021-02819-0</ref> - [https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-021-02819-0 (Full text)]
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