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Cytotoxic T-lymphocyte associated protein 4
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==ME/CFS == Steiner et al. (2021) found that patients who developed [[chronic fatigue syndrome]] after a [[virus]] were more likely to have PTPN22 and CTLA4 gene mutations.<ref name="Steiner2021"/> Dr [[Carmen Scheibenbogen]] stated: "Our finding provides evidence that ME/CFS is an [[autoimmune disease]] in the subgroup of patients whose disease is triggered by an infection. It encourages us to pursue clinical studies with [[Immunoglobulin G|IgG]] or [[immunoadsorption]] to target autoantibodies."<ref name="Steiner2021"/> A later study by Hajdarevic et al. (2022) did not find any link between ME/CFS and the CTLA4 and PTPN22 genes.*2022, Genetic association study in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) identifies several potential risk loci<ref name="Hajdarevic2022"/>
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