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Cusack Protocol
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==Risks, safety, and side effects == Risks are largely unknown due to lack of clinical trials and an absence of medical practitioners reporting on the effects of patients using the Cusack protocol.<ref name="plenary2017" /> The Cusack protocol includes eight supplements, so side effects may result from any of these or from combinations of them. Deborah Cusack has stated that some side effects will be experienced initially, and may last between one day and several weeks in EDS patients, which she refers to as the "healing curve" or a "healing crisis". Cusack states this includes [[joint stiffness|stiff joints]], [[myalgia|aching muscles]], and that [[fatigue]], [[limb w-grade|mild fever]], [[nausea]] and [[headache]] may also occur.<ref name="slides2016" /> A [[Mast cell activation disorder|mast cell disease]] flare may also occur in patients with mast cell disease, according to Cusack. There is lack of information about the impact of the protocol on people with other illnesses in addition to EDS, or effects on people without EDS.<ref name="slides2016" /> These is a lack of information about the safety and risks of taking these supplements with existing medications or other supplements.<ref name="slides2016" />
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