Coxsackievirus B4
Coxsackievirus B4 is a Coxsackie B enterovirus that belong to the Picornaviridae family.
Coxsackievirus B4 has a cell tropism for natural killer cells and pancreatic islet cells.
Type 1 Diabetes[edit | edit source]
Several studies have suggested a relationship between Coxsackie B4 and the onset of Type 1 diabetes.[1][2][3]
A study of patients with Type 1 Diabetes found that Coxsackie B4 was found to infect the β cells in the pancreatic islets of the pancreas and cause inflammation mediated by natural killer cells.[4]
Treatment[edit | edit source]
Several compounds have been found in in vitro or animals studies to have antiviral activity for Coxsackie B4 including arbidol,[5] Yakammaoto[6], raoulic acid[7], emodin[8] Epimedium, and Azadirachta indica (Neem).[9] However, none of these compounds have been evaluated in human trials.
See also[edit | edit source]
References[edit | edit source]
- ↑ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1587352/
- ↑ http://link.springer.com/article/10.1007%2Fs00125-003-1297-z
- ↑ http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0057729
- ↑ http://www.pnas.org/content/104/12/5115.full
- ↑ Zhang, S (May 2017). "Umifenovir effectively inhibits IL-10 dependent persistent Coxsackie B4 virus infection". Antiviral Research. 141: 165–173.
- ↑ https://www.ncbi.nlm.nih.gov/pubmed/24361333
- ↑ Choi, HJ (January 2009). "Antiviral activity of raoulic acid from Raoulia australis against Picornaviruses". Phytomedicine.
- ↑ Liu, Zhao (October 2013). "In Vitro and in Vivo Studies of the Inhibitory Effects of Emodin Isolated from Polygonum cuspidatum on Coxsakievirus B-4". Molecules.
- ↑ Badam, L (1999). "'In vitro' antiviral activity of neem (Azadirachta indica. A. Juss) leaf extract against group B coxsackieviruses". J Commun Dis.
