Coxsackievirus B4

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Revision as of 04:28, May 21, 2018 by Kmdenmark (talk | contribs) (copy edit; removed hyperlink (β cells are not B cells))

Coxsackievirus B4 is an enterovirus that belong to the Picornaviridae family.

Coxsackievirus B4 has a cell tropism for natural killer cells and pancreatic islet cells.

Type 1 Diabetes[edit | edit source]

Several studies have suggested a relationship between Coxsackie B4 and the onset of Type 1 diabetes.[1][2][3]

A study of patients with Type 1 Diabetes found that Coxsackie B4 was found to infect the β cells in the pancreatic islets of the pancreas and cause inflammation mediated by natural killer cells.[4]

Treatment[edit | edit source]

Several compounds have been found in in vitro or animals studies to have antiviral activity for Coxsackie B4 including Yakammaoto[5], raoulic acid[6], emodin[7] Epimedium, and Azadirachta indica (Neem).[8] However, none of these compounds have been evaluated in human trials.

See also[edit | edit source]

References[edit | edit source]