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Coverage (genetics)
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{{stub}} '''Coverage''' or '''depth''' in [[genetic]]s refers to the number of times a given nucleotide has been read for sequencing in genetic mapping.<ref>{{Cite journal | last = Ponting|first = Chris P. | last2 = Heger | first2 = Andreas | last3 = Ilott | first3 = Nicholas E. | last4 = Sudbery | first4 = Ian | last5 = Sims | first5 = David | date = Feb 2014 | title = Sequencing depth and coverage: key considerations in genomic analyses |url =https://www.nature.com/articles/nrg3642|journal=Nature Reviews Genetics|language=en|volume=15|issue=2 | pages = 121β132|doi=10.1038/nrg3642|issn=1471-0064}}</ref> While sequencing is highly accurate, the human genome has a vast number of nucleotides and so even a low error rate can produce a significant number of errors if the whole genome is only read once. Repeatedly reading a given area offers the opportunity to eliminate errors there. In 2011 paper for ''Genome Research'', Ajay et al. arqued that "the current recommendation of βΌ30Γ coverage is not adequate to produce genotype calls across a large fraction of the genome with acceptably low error rates."<ref>{{Cite journal | last = Ajay|first = Subramanian S. | last2 = Parker | first2 = Stephen C.J. | last3 = Ozel Abaan | first3 = Hatice | last4 = Fuentes Fajardo | first4 = Karin V. | last5 = Margulies | first5 = Elliott H. | date = Sep 2011 | title = Accurate and comprehensive sequencing of personal genomes |url =https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166834/|journal=Genome Research|volume=21|issue=9 | pages = 1498β1505|doi=10.1101/gr.123638.111|issn=1088-9051|pmc=3166834|pmid=21771779}}</ref> == See also == * [[:Category:Genetics|Genetics (category)]] *[[Genetic testing]] * [[Whole exome sequencing]] * [[Whole genome sequencing]] ==Learn more == ==References== {{reflist}} [[Category:Genetics]]
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