Anonymous
Not logged in
Talk
Contributions
Create account
Log in
Search
Editing
Comorbidities of Myalgic Encephalomyelitis
(section)
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
Namespaces
Page
Discussion
More
More
Page actions
Read
Edit
Edit source
History
Warning:
You are not logged in. Your IP address will be publicly visible if you make any edits. If you
log in
or
create an account
, your edits will be attributed to your username, along with other benefits.
Anti-spam check. Do
not
fill this in!
== Clinical perspectives == * In “The Nightingale Research Foundation Definition of Myalgic Encephalomyelitis (M.E.),”<ref>{{Cite book | url = https://docs.wixstatic.com/ugd/5b307e_b3a662c05f174937b9516d473a994c41.pdf | title=The Nightingale Research Foundation Definition of Myalgic Encephalomyelitis (M.E.) | last = Hyde | first = Byron| publisher = Cornell University| year = |isbn=|location= | pages = }}</ref> ME physician [[Byron Hyde]] has describes the relationship between ME, POTS/dyaustonomia, and EDS in terms of disease severity: ** “Patients with [[dysautonomia]] and/or [[Postural orthostatic tachycardia syndrome|POTS]] dysfunctions invariably demonstrated [[Cerebral hypoperfusion|hypoperfusion]] in the operculum area overlying the insular cortex as in the above patient, suggesting an insular cortex injury in our dysautonomia patients.” ** “Patients with pre-existing or newly-discovered (a) [[Ehlers-Danlos syndrome|Ehlers-Danlos Hypermobility Syndrome]], (b) Collagen diseases... are among the most disabled patients we have seen.” * A case series by [[Peter Rowe]] of adolescents referred to his clinic found 12 patients who also met the criteria for Ehlers-Danlos Syndrome and had orthostatic intolerance (postural orthostatic tachycardia or neurally-mediated hypotension). He concluded that “Among patients with CFS and orthostatic intolerance, a subset also has EDS.”<ref>{{Cite journal | title = Orthostatic intolerance and chronic fatigue syndrome associated with Ehlers-Danlos syndrome | url =http://www.sciencedirect.com/science/article/pii/S0022347699701733 | journal = The Journal of Pediatrics | date = 1999-10-01|issn=0022-3476 | pages = 494–499|volume=135 | issue = 4|doi=10.1016/S0022-3476(99)70173-3|first = Peter C. | last = Rowe | first2 = Diana F. | last2 = Barron | first3 = Hugh | last3 = Calkins | first4 = Irene H. | last4 = Maumenee | first5 = Patrick Y. | last5 = Tong | first6 = Michael T. | last6 = Geraghty}}</ref> * At a two-day physician summit in Salt Lake City, Utah March 2018, physicians discussed the relationship between “Chronic Fatigue Syndrome” and mast cell activation syndrome.<ref>{{Cite web | url = https://www.medscape.com/viewarticle/893858 | title = Medscape Log In | website = Medscape|access-date=2018-09-25}}</ref> ** [[David Kaufman]]: "ME/CFS is a descriptive diagnosis of a bunch of symptoms, but it says nothing about what's causing the symptoms, which is probably part of the reason it's so hard for it to get recognition. So, the question becomes, What other pathology is driving this illness and making the person feel so ill? I think mast cell activation is one of those drivers, whether cause, effect, or perpetuator, I don't know." ** [[Charles Lapp]]: "I see a lot of this. I think it's one of the many overlap syndromes that we've been missing for years." ** [[Susan Levine]]: "I suspect 50% to 60% of ME/CFS patients have it. It's a very new concept."...In Levine's experience, MCAS often manifests in patients being unable to tolerate certain foods or medications. "If we can reduce the mast cell problem, we can facilitate taking other drugs to treat ME/CFS," she said. However, she also cautioned, "It's going to be a subset, not all ME/CFS patients."
Summary:
Please make sure your edits are consistent with
MEpedia's guidelines
.
By saving changes, you agree to the
Terms of use
, and you irrevocably agree to release your contribution under the
CC BY-SA 3.0 License
and the
GFDL
. You agree that a hyperlink or URL is sufficient attribution under the Creative Commons license.
Cancel
Editing help
(opens in new window)
This page is a member of a hidden category:
Category:Pages using DynamicPageList
Navigation
Navigation
Skip to content
Main page
Browse
Become an editor
Random page
Popular pages
Abbreviations
Glossary
About MEpedia
Links for editors
Contents
Guidelines
Recent changes
Pages in need
Search
Help
Wiki tools
Wiki tools
Special pages
Page tools
Page tools
User page tools
More
What links here
Related changes
Page information
Page logs