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Cognitive dysfunction
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===Neurological changes in ME/CFS === [[File:MECFS-neuroeffects-brain.jpg|alt=Sketch of a brain with words inside saying intracranial hypertension, impaired cerebral blood flow, hyperventilation/hypocapnia, and adrenergic hyperactivity.|thumb|Key neurological pathomechanisms in ME/CFS.<br>'''Source:''' Wirth, K.J., Scheibenbogen, C. & Paul, F. [https://doi.org/10.1186/s12967-021-03143-3 An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.] J Transl Med 19, 471 (2021). https://doi.org/10.1186/s12967-021-03143-3]] Causes of neurological symptoms in ME/CFS include: *hyperventilation/hypnocapnia (reduced carbon dioxide levels in the blood) *[[intracranial hypertension]] (increased pressure within the skull and around brain) * reduced blood flow to the brain * [[Neuroinflammation|brain inflammation]] may also be a factor<ref name="Wirth2021b" /> Wirth, Scheibenbogen and Paul (2021) state these "can explain cognitive impairment, [[brain fog]], [[headache]], psychomotor slowing, [[ataxia]] and loss of coordination of movements, [[Sensory overload|hypersensitivity]], [[sleep dysfunction|sleep disturbances]] and [[dysautonomia]]."<ref name="Wirth2021b" />
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