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*2008, [http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD001027.pub2/abstract Cognitive behaviour therapy for chronic fatigue syndrome in adults] (Jonathan R Price, Edward Mitchell, Elizabeth Tidy, Vivien Hunot)<ref name="Cochrane2008"/>
*2008, [http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD001027.pub2/abstract Cognitive behaviour therapy for chronic fatigue syndrome in adults] (Jonathan R Price, Edward Mitchell, Elizabeth Tidy, Vivien Hunot)<ref name="Cochrane2008"/>


==Criticism==
==Criticism & Undisclosed Conflicts of Interest==
Professor [[James Coyne]] has criticized Cochrane's work assessing exercise as a treatment for [[chronic fatigue syndrome]], asking it "to consider the implications of having authors conduct a systematic review with the Cochrane collaboration brand attached who have ties to an industry which would benefit from particular conclusions. These same conclusions would personally enrich some of the authors professionally and personally", referring to the involvement of [[Trudie Chalder]], [[Rona Moss-Morris]], [[Michael Sharpe]], [[Alison Wearden]] and [[Peter White]] who are also authors of the [[PACE trial]].<ref name="Coyne20160105"/><ref name="Coyne20160320"/><ref>[https://jcoynester.wordpress.com/2016/04/23/probing-an-untrustworthy-cochrane-review-of-exercise-for-chronic-fatigue-syndrome/ Probing an untrustworthy Cochrane review of exercise for “chronic fatigue syndrome”]</ref>
Professor [[James Coyne]] has criticized Cochrane's work assessing exercise as a treatment for [[chronic fatigue syndrome]], asking it "to consider the implications of having authors conduct a systematic review with the Cochrane collaboration brand attached who have ties to an industry which would benefit from particular conclusions. These same conclusions would personally enrich some of the authors professionally and personally", referring to the involvement of [[Trudie Chalder]], [[Rona Moss-Morris]], [[Michael Sharpe]], [[Alison Wearden]] and [[Peter White]] who are also authors of the [[PACE trial]].<ref name="Coyne20160105"/><ref name="Coyne20160320"/><ref>[https://jcoynester.wordpress.com/2016/04/23/probing-an-untrustworthy-cochrane-review-of-exercise-for-chronic-fatigue-syndrome/ Probing an untrustworthy Cochrane review of exercise for “chronic fatigue syndrome”]</ref>
Prof Coyne also wrote an open letter to Cochrane in March 2016 regarding the upcoming Cochrane review and conflicts of interests <ref> https://www.coyneoftherealm.com/blogs/news/an-open-letter-to-the-cochrane-collaboration-bill-silverman-lies-a-moldering-in-his-grave </ref> <ref>  https://jcoynester.wordpress.com/2016/04/21/my-response-to-an-invitation-to-improve-the-cochrane-collaboration-by-challenging-its-policies/</ref>.


In March 2016, the 2014 Cochrane Intervention Protocol was modified to include previously undisclosed conflicts of interest for Peter White: "PDW has undertaken consultancy work for a re-insurance firm.  He has also undertaken voluntary consultancy for the Departments of Health, Work and Pensions and is a member of the Independent Medical Experts Group, a non-Governmental organisation which advises the Ministry of Defence regarding their Armed Forces Compensation Fund."<ref name="Coyne20160319"/>
In March 2016, the 2014 Cochrane Intervention Protocol was modified to include previously undisclosed conflicts of interest for Peter White: "PDW has undertaken consultancy work for a re-insurance firm.  He has also undertaken voluntary consultancy for the Departments of Health, Work and Pensions and is a member of the Independent Medical Experts Group, a non-Governmental organisation which advises the Ministry of Defence regarding their Armed Forces Compensation Fund."<ref name="Coyne20160319"/>


It was admitted in the information tribunal of April 2016 on page 31  that "Professor Chalder states that disclosure to the Cochrane review does not count as disclosure to independent scientists as all three of the PACE principal investigators sat on the review panel" <ref>  https://dl.dropboxusercontent.com/u/23608059/OCR-Queen%20Mary%20University%20of%20London%20EA-2015-0269%20%2812-8-16%29.pdf            </ref>.
On 14 April 2017 Prof James Coyne submitted a very early request for the data to Cochrane along with an open letter <ref> https://jcoynester.wordpress.com/2017/04/13/why-i-am-formally-requesting-the-data-set-from-a-cochrane-review/ </ref>.


It was admitted in the information tribunal of April 2016 on page 31  that "Professor Chalder states that disclosure to the Cochrane review does not count as disclosure to independent scientists as all three of the PACE principal investigators sat on the review panel" <ref>   https://dl.dropboxusercontent.com/u/23608059/OCR-Queen%20Mary%20University%20of%20London%20EA-2015-0269%20%2812-8-16%29.pdf            </ref>.
A liaison psychiatrist publishing in the British Journal of Psychiatry has criticised the 'Exercise Therapy for CFS' for being heavily influenced by the [[PACE trial]]  <ref> http://www.meassociation.org.uk/2017/05/liaison-psychiatrist-suggests-that-cochrane-review-on-exercise-therapy-in-cfs-was-heavily-influenced-by-controversial-pace-trial-6-may-2017/</ref>.


On 14 April Prof James Coyne submitted a very early request for the data to Cochrane along with an open letter <ref> https://jcoynester.wordpress.com/2017/04/13/why-i-am-formally-requesting-the-data-set-from-a-cochrane-review/ </ref>.
One of the authors of the Cochrane review Kjell Gundro Brurberg misrepresented the conflicts of interest of himself and his reviewers regarding  the PACE trial  after being given a number of opportunities to do so  for an article he was invited to publish in the Journal of Health Psychology in what has been described as "scientific misconduct"    <ref> https://www.coyneoftherealm.com/blogs/news/misconduct-in-an-author-s-nomination-of-reviewers-for-his-manuscriptç </ref>.


==Online presence==
==Online presence==

Revision as of 14:15, July 19, 2017

Cochrane Logo.png

Cochrane (previously called the Cochrane Collaboration) is an independent, non-profit organization run by volunteers around the world which conducts systematic reviews of randomized controlled trials of health-care interventions and diagnostic tests, which it publishes in The Cochrane Library.

Chronic fatigue syndrome[edit | edit source]

Cochrane lists chronic fatigue syndrome under its "neurology" and "mental health" categories[1] and its chronic fatigue syndrome reviews are produced by its "Mental Disorders Group". It has published some reviews assessing treatments for chronic fatigue syndrome:

Criticism & Undisclosed Conflicts of Interest[edit | edit source]

Professor James Coyne has criticized Cochrane's work assessing exercise as a treatment for chronic fatigue syndrome, asking it "to consider the implications of having authors conduct a systematic review with the Cochrane collaboration brand attached who have ties to an industry which would benefit from particular conclusions. These same conclusions would personally enrich some of the authors professionally and personally", referring to the involvement of Trudie Chalder, Rona Moss-Morris, Michael Sharpe, Alison Wearden and Peter White who are also authors of the PACE trial.[5][6][7]

Prof Coyne also wrote an open letter to Cochrane in March 2016 regarding the upcoming Cochrane review and conflicts of interests [8] [9].

In March 2016, the 2014 Cochrane Intervention Protocol was modified to include previously undisclosed conflicts of interest for Peter White: "PDW has undertaken consultancy work for a re-insurance firm. He has also undertaken voluntary consultancy for the Departments of Health, Work and Pensions and is a member of the Independent Medical Experts Group, a non-Governmental organisation which advises the Ministry of Defence regarding their Armed Forces Compensation Fund."[10]

It was admitted in the information tribunal of April 2016 on page 31 that "Professor Chalder states that disclosure to the Cochrane review does not count as disclosure to independent scientists as all three of the PACE principal investigators sat on the review panel" [11].

On 14 April 2017 Prof James Coyne submitted a very early request for the data to Cochrane along with an open letter [12].

A liaison psychiatrist publishing in the British Journal of Psychiatry has criticised the 'Exercise Therapy for CFS' for being heavily influenced by the PACE trial [13].

One of the authors of the Cochrane review Kjell Gundro Brurberg misrepresented the conflicts of interest of himself and his reviewers regarding the PACE trial after being given a number of opportunities to do so for an article he was invited to publish in the Journal of Health Psychology in what has been described as "scientific misconduct" [14].

Online presence[edit | edit source]

Learn more[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

  1. ↑ List of Cochrane articles on chronic fatigue syndrome
  2. ↑ Larun, Lillebeth; Brurberg, Kjetil G.; Odgaard-Jensen, Jan; Price, Jonathan R (February 7, 2016), "Intervention Review: Exercise therapy for chronic fatigue syndrome", Cochrane Library, doi:10.1002/14651858.CD003200.pub4
  3. ↑ Larun, Lillebeth; Odgaard-Jensen, Jan; Brurberg, Kjetil G.; Chalder, Trudie; Dybwad, Marianne; Moss-Morris, Rona; Sharpe, Michael; Wallman, Karen; Wearden, Alison; White, Peter D; Glasziou, Paul P (April 1, 2014), "Intervention Protocol: Exercise therapy for chronic fatigue syndrome (individual patient data)", Cochrane Library, doi:10.1002/14651858.CD011040
  4. ↑ Price, Jonathan R; Mitchell, Edward; Tidy, Elizabeth; Hunot, Vivien (July 16, 2008), "Intervention Review: Cognitive behaviour therapy for chronic fatigue syndrome in adults", Cochrane Library, doi:10.1002/14651858.CD001027.pub2
  5. ↑ Coyne, James (January 5, 2016), "Undisclosed conflicts of interest in a systematic review protocol of interventions for medically unexplained symptoms", QuickThoughts Blog
  6. ↑ Coyne, James (March 20, 2016), "Why the Cochrane Collaboration needs to clean up conflicts of interest", QuickThoughts Blog
  7. ↑ Probing an untrustworthy Cochrane review of exercise for “chronic fatigue syndrome”
  8. ↑ https://www.coyneoftherealm.com/blogs/news/an-open-letter-to-the-cochrane-collaboration-bill-silverman-lies-a-moldering-in-his-grave
  9. ↑ https://jcoynester.wordpress.com/2016/04/21/my-response-to-an-invitation-to-improve-the-cochrane-collaboration-by-challenging-its-policies/
  10. ↑ Coyne, James (March 19, 2016), "Update to: Undisclosed conflicts of interest in a systematic review protocol of interventions for medically unexplained symptoms", Quick Thoughts Blog
  11. ↑ https://dl.dropboxusercontent.com/u/23608059/OCR-Queen%20Mary%20University%20of%20London%20EA-2015-0269%20%2812-8-16%29.pdf
  12. ↑ https://jcoynester.wordpress.com/2017/04/13/why-i-am-formally-requesting-the-data-set-from-a-cochrane-review/
  13. ↑ http://www.meassociation.org.uk/2017/05/liaison-psychiatrist-suggests-that-cochrane-review-on-exercise-therapy-in-cfs-was-heavily-influenced-by-controversial-pace-trial-6-may-2017/
  14. ↑ https://www.coyneoftherealm.com/blogs/news/misconduct-in-an-author-s-nomination-of-reviewers-for-his-manuscriptç

randomized controlled trial (RCT) - A trial in which participants are randomly assigned to two groups, with one group receiving the treatment being studied and a control or comparison group receiving a sham treatment, placebo, or comparison treatment.

PACE trial A controversial study which claimed that CBT and GET were effective in treating "CFS/ME", despite the fact that its own data did not support this conclusion. Its results and methodology were widely disputed by patients, scientists, and the peer-reviewed scientific literature.

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