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Christopher Larrimore
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'''Christopher Larrimore''', BS, MS, is an osteopathic medical student at [[Nova Southeastern University]] and conducts research examining the hypothesized role of [[folate]] in [[myalgic encephalomyelitis]] (ME). ==Early life and education== Larrimore, who is from Maryland, US, served four years in the US Coast Guard before enrolling in the University of Maryland, where he earned a Bachelor of Science. He next earned a Master in Science from Johns Hopkins University, Maryland.<ref name=":0">{{Cite web | url = https://www.meaction.net/2019/07/24/announcing-meactions-blue-ribbon-fellow-investigating-the-role-of-folate-in-me/ | title = Announcing #MEAction's Blue Ribbon Fellow: Investigating the Role of Folate in ME | date = 2019-07-24 | website = #MEAction|language=en-US|access-date=2019-07-27}}</ref> He next conducted research for two years before beginning medical school at Dr. Kiran C. Patel College of Osteopathic Medicine (NSU-KPCOM) at [[Nova Southeastern University]]. In 2019, he begins his fourth year of medical school.<ref name=":0" /> ==Research== On a two-year research fellowship from the Johns Hopkins University, Larrimore investigated blood vessel growth in response to tumor formation.<ref name=":0" /> After matriculation into medical school, he began pursuing ME research on a one-year research fellowship at NSU-KPCOM.<ref name=":0" /> His current ME research examines genetics and a hypothesized role of 5-MTHF (active [[folate]], [[methylfolate]], or [[Vitamin B9]]) in people with ME.<ref name=":0" /> [[Methylation]] is a mechanism central to the functioning of numerous biochemical pathways, including in cardiovascular, neurological, reproductive, energy production and detoxification biochemical systems.<ref name=":0" /> If a genetic variant reducing available 5-[[MTHFR]] is present, it reduces the body's ability to activate these systems, possibly producing fatigue such as seen in the clinical presentation of ME.<ref name=":0" /> To examine this possible link to ME, Larrimore used a genetic database developed by Dr. [[Nancy Klimas]]βs team at the NSU [[Institute of Neuro-Immune Medicine]] to identify persons with a MTHFR gene mutation and recruit for a small, proof-of-concept study of the role of folate in ME.<ref name=":0" /> Over three months in a double-blinded study, subjects took either daily methylfolate supplement or a placebo and outcomes were measured both by serum biomarkers and self-reported symptoms. In July 2019, he was awarded a Blue Ribbon Fellowship from [[The MEAction Network]] to continue this project.<ref name=":0" /> ==Publications== * 2019, Understanding Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and the Emerging Osteopathic Approach: A Narrative Review.<ref>{{Cite journal | last = Larrimore | first = Christopher | authorlink = Christopher Larrimore | last2 = Ramnot | first2 = Amanda | author-link2 = Amanda Ramnot | last3 = Jaghab | first3 = Annmarie | author-link3 = Annmarie Jaghab | last4 = Sarduy | first4 = Sofia | author-link4 = Sofia Sarduy | last5 = Guerrero | first5 = George | author-link5 = George Guerrero | last6 = Troccoli | first6 = Peter | author-link6 = Peter Troccoli | last7 = Hilton | first7 = Kelly | author-link8 = Kelly Hilton | last8 = Bested | first8 = Alison | author-link8 = Alison Bested | date = 2019-07-01 | title = Understanding Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and the Emerging Osteopathic Approach: A Narrative Review | url =http://jaoa.org/article.aspx?doi=10.7556/jaoa.2019.081 | journal = The Journal of the American Osteopathic Association|language=en | volume = 119 | issue = 7 | pages = 446|doi=10.7556/jaoa.2019.081|issn=0098-6151|quote=|via=}}</ref> ==References== {{reflist}} [[Category:US researchers]]
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