Anonymous
Not logged in
Talk
Contributions
Create account
Log in
Search
Editing
Central sensitization
(section)
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
Namespaces
Page
Discussion
More
More
Page actions
Read
Edit
Edit source
History
Warning:
You are not logged in. Your IP address will be publicly visible if you make any edits. If you
log in
or
create an account
, your edits will be attributed to your username, along with other benefits.
Anti-spam check. Do
not
fill this in!
== The physiological mechanism == The physiology of central sensitization involves the activation of unmyelinated C-fibers that release excitatory neuropeptides such as [[glutamate]], tachykinins and substance P in the dorsal horn of the [[spinal cord]].<ref name=":9" /> A primary role is played by the [[neurotransmitter]] glutamate which activates N-methyl-D-aspartic acid (NMDA) receptors. Normally, the ion channel of these NMDA-receptors is blocked by a magnesium ion, but the block can be removed by a depolarization of the cell leading to an influx of calcium, which leads to further depolarization. These changes cause an escalation of hyperexcitability of spinal cord neurons, giving rise to a hypersensitivity to noxious stimuli.<ref>{{Cite journal | last = Woolf | first = Clifford J. | last2 = Chong | first2 = Mun-Seng | date = Aug 1993 | title = Preemptive Analgesia—Treating Postoperative Pain by Preventing the Establishment of Central Sensitization | url =http://dx.doi.org/10.1213/00000539-199377020-00026 | journal = Anesthesia & Analgesia | volume = 77 | issue = 2 | pages = 362–379|doi=10.1213/00000539-199377020-00026|issn=0003-2999|quote= | authorlink = Clifford Woolf | author-link2 = Mun-Seng Cheng|via=}}</ref><ref>{{Cite journal | last = DeLeo | first = Joyce A. | last2 = Winkelstein | first2 = Beth A. | date = Nov 2002 | title = Physiology of Chronic Spinal Pain Syndromes |url =http://dx.doi.org/10.1097/00007632-200211150-00026 | journal = Spine | volume = 27 | issue = 22 | pages = 2526–2537|doi=10.1097/00007632-200211150-00026|issn=0362-2436}}</ref> Nitric oxide (NO) also plays a role in CS as it has been shown to modulate neuron excitability through multiple mechanisms.<ref>{{Cite journal | last = Luo | first = Z. David | last2 = Cizkova | first2 = Dasa | date = Dec 2000 | title = The role of nitric oxide in nociception | url =http://dx.doi.org/10.1007/s11916-000-0070-y | journal = Current Review of Pain | volume = 4 | issue = 6 | pages = 459–466|doi=10.1007/s11916-000-0070-y|issn=1069-5850}}</ref>
Summary:
Please make sure your edits are consistent with
MEpedia's guidelines
.
By saving changes, you agree to the
Terms of use
, and you irrevocably agree to release your contribution under the
CC BY-SA 3.0 License
and the
GFDL
. You agree that a hyperlink or URL is sufficient attribution under the Creative Commons license.
Cancel
Editing help
(opens in new window)
Navigation
Navigation
Skip to content
Main page
Browse
Become an editor
Random page
Popular pages
Abbreviations
Glossary
About MEpedia
Links for editors
Contents
Guidelines
Recent changes
Pages in need
Search
Help
Wiki tools
Wiki tools
Special pages
Page tools
Page tools
User page tools
More
What links here
Related changes
Page information
Page logs