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Central sensitization
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== Cognitive-emotional sensitization == A related concept to CS is cognitive-emotional sensitization, as put forward by Jos Brosschot in 2002. In his theory sensitization is presented as a psychological concept, related to anxiety and cognitive bias. According to Brosschot “those who have an extreme concern about somatic disease will develop a cognitive bias for information related to somatic disease. This bias would be reflected in an activated cognitive network that guides the brain into early detection of all information related to patients’ concerns.”<ref>{{Cite journal | last = Brosschot | first = Jos F. | date = Apr 2002 | title = Cognitive-emotional sensitization and somatic health complaints |url =http://dx.doi.org/10.1111/1467-9450.00276 | journal = Scandinavian Journal of Psychology | volume = 43 | issue = 2 | pages = 113–121|doi=10.1111/1467-9450.00276|issn=0036-5564}}</ref> A similar hypothesis was made by the Norwegians Olger Ursin and Hege Eriksen. In 2004 they suggested that “sensitization is the psychobiological mechanism explaining the individual differences in tolerance and acceptance of common health complaints.”<ref>{{Cite journal | last = Eriksen | first = H.R | last2 = Ursin | first2 = H | date = Apr 2004 | title = Subjective health complaints, sensitization, and sustained cognitive activation (stress) | url = http://dx.doi.org/10.1016/s0022-3999(03)00629-9 | journal = Journal of Psychosomatic Research | volume = 56 | issue = 4 | pages = 445–448|doi=10.1016/s0022-3999(03)00629-9|issn=0022-3999}}</ref> Mohammed Yunus has criticized these mere psychological interpretations of (central) sensitization. He emphasizes that central sensitivity syndromes have an “objective pathology of neurochemistry and neuroimaging that explain many symptoms of CSS diseases”. The same argument was made by the authors of the 2014 CS-criteria, who wrote: “CS is not a disorder of the mind, but rather a disease of the brain and spinal cord.” In 2015 Gracely & Schweinhardt presented an original hypothesis. They suggest that the symptoms of CSS should not be regarded as a direct consequence of a disease state or a pathological process but rather as an adaptive reaction of the body, similar to a sickness response. In their view the purpose of CS is to promote quiescence by inhibiting and limiting the normal range of behavior, which would lead to an increased survival from an evolutionary point of view.<ref name=":11" />
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