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Cardiovascular problems in ME/CFS
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'''Cardiac and cardiovascular problems''' occur as part of a wide range of signs and symptoms in [[ME/CFS]]. ===Circulatory problems in the [[Canadian Consensus Criteria]] for ME/CFS=== {{:List of symptoms in ME CFS/Canadian/Circulatory}}<ref name="canadianconsensus-CCC">{{Citation | last1 = Carruthers | first1 = Bruce M. | author-link1 = Bruce Carruthers | last2 = Jain | first2 = Anil Kumar | author-link2 = Anil Kumar Jain | last3 = De Meirleir | first3 = Kenny L. | author-link3 = Kenny De Meirleir | last4 = Peterson | first4 = Daniel L. | author-link4 = Daniel Peterson | last5 = Klimas | first5 = Nancy G. | author-link5 = Nancy Klimas | last6 = Lerner | first6 = A. Martin | author-link6 = Martin Lerner | last7 = Bested | first7 = Alison C. | author-link8 = Alison Bested | last8 =Flor-Henry | first8 = Pierre | author-link8 = Pierre Flor-Henry | last9 = Joshi | first9 = Pradip | author-link9 = Pradip Joshi | last10 = Powles | first10 = AC Peter | author-link10 = A C Peter Powles | last11 = Sherkey | first11 = Jeffrey A. | author-link11 = Jeffrey Sherkey | last12 = van de Sande | first12 = Marjorie I. | author-link12 = Marjorie van de Sande | title = Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Clinical Working Case Definition, Diagnostic and Treatment Protocols| journal = Journal of Chronic Fatigue Syndrome | volume = 11 | issue = 2 | pages = 7-115 | date = 2003 | pmid = | doi = 10.1300/J092v11n01_02| url = http://www.investinme.org/Documents/PDFdocuments/CanadianDefinitionME-CFS.pdf}}</ref> ===ME [[International Consensus Criteria]] symptoms=== Cardiovascular symptoms may include (but are not limited to): *inability to tolerate an upright position - which includes: ** [[orthostatic intolerance]] (OI) **[[neurally mediated hypotension]] **[[postural orthostatic tachycardia syndrome]] (POTS) *[[heart palpitation]]s with or without [[arrhythmia|cardiac arrhythmias]] *[[lightheadedness]]/[[dizziness]] *[[tachycardia]]<ref name="ICC2011primer">{{citation | last1 = Carruthers | first1 = BM | author-link1 = Bruce Carruthers | last2 = van de Sande | first2 = MI | author-link2 = Marjorie van de Sande | last3 = De Meirleir | first3 = KL | author-link3 = Kenny de Meirleir | last4 = Klimas | first4 = NG | author-link4 = Nancy Klimas | last5 = Broderick | first5 = G | author-link5 = Gordon Broderick | last6 = Mitchell | first6 = T | author-link6 = Terry Mitchell | last7 = Staines | first7 = D | author-link8 = Donald Staines | last8 = Powles | first8 = ACP | author-link8 = A C Peter Powles | last9 = Speight | first9 = N | author-link9 = Nigel Speight | last10 = Vallings | first10 = R | author-link10 = Rosamund Vallings | last11 = Bateman | first11 = L | author-link11 = Lucinda Bateman | last12 = Bell | first12 = DS | author-link12 = David Bell | last13 = Carlo-Stella | first13 = N | author-link13 = Nicoletta Carlo-Stella | last14 = Chia | first14 = J | author-link14 = John Chia | last15 = Darragh | first15 = A | author-link15 = Austin Darragh | last16 = Gerken | first16 = A | author-link16 = Anne Gerken | last17 = Jo | first17 = D | author-link17 = Daehyun Jo | last18 = Lewis | first18 = DP | author-link18 = Donald Lewis | last19 = Light | first19 = AR | author-link19 = Alan Light | last20 = Light | first20 = KC | author-link20 = Kathleen Light | last21 = Marshall-Gradisnik | first21 = S | author-link21 = Sonya Marshall-Gradisnik | last22 = McLaren-Howard | first22 = J | author-link22 = John McLaren-Howard | last23 = Mena | first23 = I | author-link23 = Ismael Mena | last24 = Miwa | first24 = K | author-link24 = Kunihisa Miwa | last25 = Murovska | first25 = M | author-link25= Modra Murovska | last26 = Stevens | first26 = SR | author-link26 = Staci Stevens | title = Myalgic encephalomyelitis: Adult & Paediatric: International Consensus Primer for Medical Practitioners | date = 2012| isbn = 978-0-9739335-3-6 | url = http://www.investinme.org/Documents/Guidelines/Myalgic%20Encephalomyelitis%20International%20Consensus%20Primer%20-2012-11-26.pdf}}</ref> ===The [[Institute of Medicine]] (2015) symptoms=== * [[dysautonomia]], including: ** [[neurally mediated hypotension]] ** [[orthostatic intolerance]] ** [[Postural orthostatic tachychardia|postural orthostatic tachycardia]]<ref name="IOM2015MECFS">{{citation | last =Institute of Medicine (US) | author-link =Institute of Medicine | last2 = Committee on the Diagnostic Criteria for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome | title = Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness | date = Feb 10, 2015 | url = http://iom.nationalacademies.org/Reports/2015/ME-CFS.aspx}}</ref> ===Other symptoms === * [[arrhythmia]] * [[bradycardia]] (slow heart rate) * [[chest pain]] * [[dyspnea]] (breathlessness) * [[endothelial dysfunction]] * [[heart rate variability]] abnormalities * [[hypotension]] (low blood pressure) * [[low blood volume]]<ref name="Newton, 2016" /> * [[poor circulation]] (including [[cold hands and feet]])<ref>{{Cite book | title = Chronic Fatigue Syndrome Treatment: A Treatment Guide | last = Verrillo | first = Erica| publisher = Erica Verrillo| year = 2012|isbn=|edition=2nd|location= | pages = |quote= | author-link = Erica Verrillo}}</ref> * [[reduced cardiac volume]]<ref name="Tomas, 2017" /> * [[small heart syndrome]]<ref name="Miwa, 2008" /> * small left ventricle (in the heart)<ref name="Miwa2015" /> and * [[short QT interval]]<ref name="Naschitz, 2006" /> ==Notable studies== *2006, Shortened QT interval: a distinctive feature of the dysautonomia of chronic fatigue syndrome<ref name="Naschitz, 2006">{{Cite journal | last1 = Naschitz | first1 = J | author-link1 = | last2 = Fields | first2 = M | author-link2 = | last3 = Isseroff | first3 = H | author-link3 = | last4 = Sharif | first4 = D | author-link4 = | last5 = Sabo | first5 = E | author-link5 = | last6 = Rosner | first6 = I | author-link6 = | title = Shortened QT interval: a distinctive feature of the dysautonomia of chronic fatigue syndrome | url = https://pubmed.ncbi.nlm.nih.gov/16895768 | journal = Journal of Electrocardiology | volume = 39 | issue = 4 | page = 389-94 | date = 2006 | pmid = 16895768 | doi = 10.1016/j.jelectrocard.2005.10.014}}</ref> - [https://pubmed.ncbi.nlm.nih.gov/16895768 (Abstract)] *2008, Small Heart Syndrome in Patients with Chronic Fatigue Syndrome<ref name="Miwa, 2008">{{Cite journal | url = https://pubmed.ncbi.nlm.nih.gov/18636530 | last =Miwa | first1 = Kunihisa | author-link1 = | last2 = Fujita | first2 = Masatoshi | author-link2 = | title = Small Heart Syndrome in Patients with Chronic Fatigue Syndrome | journal = Clinical Cardiology | volume = 31 | issue = 7 | page = 328β333 | date = 2008 | pmid = 18636530 | doi = 10.1002/clc.20227}}</ref> - [https://pubmed.ncbi.nlm.nih.gov/18636530 (Abstract)] *2015, Cardiac dysfunction and orthostatic intolerance in patients with myalgic encephalomyelitis and a small left ventricle<ref name="Miwa2015">{{Cite journal | last = Miwa | first = Kunihisa | title = Cardiac dysfunction and orthostatic intolerance in patients with myalgic encephalomyelitis and a small left ventricle | journal = Heart and Vessels | volume = 30 | issue = 4| pages = 484β489 | date = Jul 2015 | pmid = 24736946 | doi = 10.1007/s00380-014-0510-y | url = http://www.ncbi.nlm.nih.gov/pubmed/24736946}}</ref> - [http://www.ncbi.nlm.nih.gov/pubmed/24736946 (Abstract)] *2016, Reduced cardiac volumes in chronic fatigue syndrome associate with plasma volume but not length of disease: a cohort study<ref name="Newton, 2016">{{Cite journal | last = Newton | first1 = Julia L. | author-link1 = Julia Newton | last2 = Finkelmeyer | first2 = Andreas | author-link2 = | last3 = Petrides | first3 = George | author-link3 = | last4 = Frith | first4 = James| author-link4 = | last5 = Hodgson | first5 = Tim | author-link5 = | last6 = Maclachlan | first6 = Laura| author-link6 = | last7 = MacGowan | first7 = Guy | author-link7 = | last8 =Blamire | first8 = Andrew M. | author-link8 = | title = Reduced cardiac volumes in chronic fatigue syndrome associate with plasma volume but not length of disease: a cohort study | url = https://openheart.bmj.com/content/openhrt/3/1/e000381.full.pdf | journal = Open Heart | volume = 3 | issue = 1 | page = | date = 2016 | doi = 10.1136/openhrt-2015-000381}}</ref> - [https://openheart.bmj.com/content/openhrt/3/1/e000381.full.pdf (Full text)] *2016, Chronic fatigue syndrome in women assessed with combined cardiac magnetic resonance imaging<ref name="Olimulder, 2016">{{Cite journal | last =Olimulder | first1 = MA | author-link1 = | last2 = Galjee | first2 = MA | author-link2 = | last3 = Wagenaar | first3 = LJ | author-link3 = | last4 = van Es | first4 = J | author-link4 = | last5 = van der Palen | first5 = J | author-link5 = | last6 = Visser | first6 = FC | author-link6 = | last7 = Vermeulen | first7 = RC | author-link7 = | last8 =von Birgelen | first8 = C | author-link8 = | title = Chronic fatigue syndrome in women assessed with combined cardiac magnetic resonance imaging. | journal = Netherlands Heart Journal | volume = | issue = | page = | date = 2016 | url = https://link.springer.com/article/10.1007/s12471-016-0885-8 | pmid = 27561279 | doi = 10.1007/s12471-016-0885-8}}</ref> - [https://link.springer.com/article/10.1007/s12471-016-0885-8 (Full Text)] *2017, Elevated brain natriuretic peptide levels in chronic fatigue syndrome associate with cardiac dysfunction: a case control study<ref name="Tomas, 2017">{{Cite journal | last =Tomas | first1 = Cara| author-link1 = Cara Tomas | last2 = Finkelmeyer | first2 = Andreas | author-link2 = Andreas Finkelmeyer | last3 = Hodgson | first3 = Tim | author-link3 = | last4 = MacLachlan | first4 = Laura | author-link4 = | last5 = MacGowan | first5 = Guy A | author-link5 = | last6 = Blamire | first6 = Andrew M | author-link6 = | last7 = Newton | first7 = Julia L | author-link8 = Julia Newton | title = Elevated brain natriuretic peptide levels in chronic fatigue syndrome associate with cardiac dysfunction: a case control study | journal = Open Heart | volume = | issue = | page = | date = 2017 | pmid = | doi = 10.1136/openhrt-2017-000697 | url = https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5761285/}}</ref> - [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5761285/ (Full text)] *2018, Cardiovascular characteristics of chronic fatigue syndrome<ref name="Bozzini, 2018">{{Cite journal | last =Bozzini | first1 = S | author-link1 = | last2 = Albergati | first2 = A | author-link2 = | last3 = Capelli | first3 = Enrica | author-link3 = Enrica Capelli | last4 = Lorusso | first4 = Lorenzo | author-link4 = Lorenzo Lorusso | last5 = Gazzaruso | first5 = C | author-link5 = | last6 = Pelissero | first6 = G | author-link6 = | last7 = Falcone | first7 = C | author-link8 = | title = Cardiovascular characteristics of chronic fatigue syndrome. | journal = Biomedical Reports | volume = 8 | issue = 1 | page = 26β30 | date = 2018 | url = https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772628 | pmc = PMC5772628 | pmid = 29399336 | doi = 10.3892/br.2017.1024}}</ref> - [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772628/ (Full Text)] *2019, Evidence of altered cardiac autonomic regulation in myalgic encephalomyelitis/chronic fatigue syndrome<ref name="Nelson2019">{{Cite journal | last1 = Nelson | first1 = Maximillian J | author-link = n | last2 = Bahl | first2 = Jasvir S | author-link2 = | last3 = Buckley | first3 = Jonathan D | author-link3 = | last4 = Thomson | first4 = Rebecca L | author-link4 = | last5 = Davison | first5 = Kade | author-link5 = | title = Evidence of altered cardiac autonomic regulation in myalgic encephalomyelitis/chronic fatigue syndrome |journal = Medicine (Baltimore)|volume = 98|issue = 43| page = e17600| date = Oct 2019| url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824690/| pmc = PMC6824690 |doi= 10.1097/MD.0000000000017600}}</ref> - [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824690/ (Full text)] == See also == *[[Endothelial dysfunction]] * [[:Category:Cardiac signs and symptoms|Cardiac signs and symptoms list]] * [[:Category:Vascular signs and symptoms|Vascular signs and symptoms list]] * [[Two-day cardiopulmonary exercise test]] * [[Invasive cardiopulmonary exercise test]] ==Learn more== * [https://www.healthrising.org/blog/2013/11/01/heart-palpitations-heart-poundin-heart-fluttering-oh-lord-cardiologist-heart-racing-arrythmias-chronic-fatigue-syndrome/ Heart Palpitations, Heart Pounding and Heart Fluttering - Oh Lord!..A Cardiologist on Heart Racing and Arrhythmias in Chronic Fatigue Syndrome] - Health Rising *[https://www.masscfids.org/resource-library/3-research/108-cardiac-symptoms-and-abnormalities-documented-in-cfs-patients-a-summary-of-4-studies-by-lerner-et-al "Cardiac Symptoms and Abnormalities Documented in CFS Patients: (A summary of 4 studies by Lerner et al.)" by the] [[Massachusetts CFIDS/ME & FM Association]] ==References== {{Reflist}} [[Category:Signs and symptoms]] [[Category:Cardiac signs and symptoms]] [[Category:Cardiology]] [[Category:Cardiovascular signs and symptoms]] [[Category:Vascular signs and symptoms]]
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