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Cancer-related fatigue
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==Differences from ME/CFS== ===Disease process=== Cancer-related fatigue and chronic fatigue syndrome have some similarities but are believed to have different underlying disease mechanisms, and affect the body differently. Fatigue can be one of several early symptoms of cancer, or may be triggered by cancer treatment.<ref name="diff">{{Cite journal | last = Park | first = Hye Youn | author-link = | last2 = Jeon | first2 = Hong Jun | author-link2 = | last3 = Bang | first3 = Young Rong | author-link3 = | last4 = Yoon | first4 = In-Young | author-link4 = | date = January 2019 | title = Multidimensional Comparison of Cancer-Related Fatigue and Chronic Fatigue Syndrome: The Role of Psychophysiological Markers |url =https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354035/ | journal = Psychiatry Investigation | volume = 16 | issue = 1 | pages = 71β79|doi=10.30773/pi.2018.10.26|issn=1738-3684|pmc=6354035|pmid=30605994|access-date=|quote=|via=}}</ref> Differences include different EEG findings, different hs-CRP levels and different heart rate variability.<ref name="diff"/> ===Symptoms === [[Post-exertional malaise]] (PEM) is increasingly regarded as the hallmark symptom in ME/CFS, but is only found in a minority of people with cancer-related fatigue. Cancer-related fatigue was found to more closely linked to sleep quality, anxiety and depression compared to chronic fatigue syndrome.<ref name="diff" /> ===Diagnostic criteria === Cancer-related fatigue cannot be diagnosed without a clear test indicating that cancer is present. ME/CFS is not diagnosed if an alternative explanation is present for the symptoms, such as an untreated fatiguing illness, although this does depend on the diagnostic criteria used. ===Risk factors === [[File:Cancer-fatigue-risk-factors.jpg|thumb|'''Risk factors in cancer-related fatigue.''' Source: Cells. 2019 Jul; 8(7): 738. ]] [[risk factors|Triggers and risk factors]] differ significantly between ME/CFS and cancer-related fatigue.<ref name="PMC6679212">{{Cite journal | last = Yang | first = Songwei | last2 = Chu | first2 = Shifeng | last3 = Gao | first3 = Yan | last4 = Ai | first4 = Qidi | last5 = Liu | first5 = Yingjiao | last6 = Li | first6 = Xun | last7 = Chen | first7 = Naihong | date = 2019-07-18 | title = A Narrative Review of Cancer-Related Fatigue (CRF) and Its Possible Pathogenesis |url =https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679212/ | journal = Cells | volume = 8 | issue = 7|doi=10.3390/cells8070738|issn=2073-4409|pmc=6679212|pmid=31323874 | pages = 738|quote=|access-date=|via=}}</ref> ME/CFS is mostly commonly associated with a sudden rather than gradual onset, and often begins after an infection, particularly a virus, although many other events may trigger ME/CFS include accidents and injuries, and surgery. Cancer-related fatigue (CRF) is associated with different demographics, for example older patients and obesity is a significant risk factor, plus the type of cancer, the cancer treatment schedule, plus specific anti-cancer drugs and treatments.<ref name="PMC6679212" /> ===Treatment === Treatment for [[chronic fatigue syndrome]] differs significantly from the treatment of cancer-related fatigue. [[Post-exertional malaise|Exercise intolerance]] is a hallmark of ME/CFS and [[Graded exercise therapy|exercise therapy]] is linked to worsening symptoms in the vast majority of ME/CFS patients, but [[exercise]] often improves cancer-related fatigue.<ref name="diff" />
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