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{{stub}} This article contains information on '''cancer''' in people with ME/CFS, and the the use of drugs developed for cancer in people with [[ME/CFS]]. For information about post-cancer fatigue, see [[cancer-related fatigue]]. ==Signs and symptoms== ==Treatment== In isolated cases, certain ME/CFS patients undergoing cancer treatment found that their ME/CFS symptoms improved. This has led to clinical trials of a few specific cancer ME/CFS drugs.<ref name="Rekeland2020"/> ==ME/CFS== A study by Chang et al. (2012) found that a history of [[chronic fatigue syndrome]] was associated with an increased risk of certain [[Non-Hodgkin lymphoma]]s, specifically diffuse large [[B cell]] lymphoma, marginal zone lymphoma, and B cell [[Non-Hodgkin lymphoma]] not otherwise specified.<ref name="Chang, 2012"/> ===Ampligen=== [[Ampligen]] (rintatolimod) is an unlicensed, experimental drug originally developed for cancer. {{See also|Ampligen}} ===Cyclophosphamide === An observational study of ME/CFS patients with cancer who were prescribed cyclophosphamide for their cancers, showed unexpected improvements in ME/CFS symptoms.<ref name="Rekeland2020"/> {{See also|Cyclophosphamide}} ===Rituximab=== Rituximab, a drug used for [[leukemia]],<ref "rituximab-cancer">https://www.cancer.gov/about-cancer/treatment/drugs/rituximab</ref> has been through several clinical trials for ME/CFS patients, but failed in a phase III clinical trial.{{citation needed | date = 2022}} {{See also|Rituximab}} ==Notable studies== * 2020, Intravenous Cyclophosphamide in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. An Open-Label Phase II Study<ref name="Rekeland2020">{{Cite journal | last = Rekeland | first = Ingrid G. | author-link = | last2 = Fosså| first2 = Alexander | author-link2 = | last3 = Lande | first3 = Asgeir | author-link3 = | last4 = Ktoridou-Valen | first4 = Irini | author-link4 = | last5 = Sørland | first5 = Kari | author-link5 = | last6 = Holsen | first6 = Mari | author-link6 = | last7 = Tronstad | first7 = Karl J. | author-link8 = Karl Tronstad | last8 = Risa | first8 = Kristin | author-link8 = | last9 = Alme | first9 = Kine | author-link9 = | date = 2020 | title=Intravenous Cyclophosphamide in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. An Open-Label Phase II Study | url = https://www.frontiersin.org/articles/10.3389/fmed.2020.00162/full | journal = Frontiers in Medicine|language=English | volume = 7 | issue = | pages = 162|pmc=PMC7201056|pmid=32411717|doi=10.3389/fmed.2020.00162|issn=2296-858X|quote=|via= | last10 = Viken | first10 = Marte K. | author-link10 = | last11 = Lie | first11 = Benedicte K. | author-link11 = | last12 = Dahl | first12 = Olav | author-link12 = | last13 = Mella | first13 = Olav | author-link13 = Olav Mella | first14 = Øystein | last14 = Fluge | author-link14 = Øystein Fluge}}</ref> - [https://www.frontiersin.org/articles/10.3389/fmed.2020.00162/full? (Full text)] *2016, [[Causes of death|Mortality]] in patients with myalgic encephalomyelitis and chronic fatigue syndrome<ref name="McManimen,Stephanie 2016">{{Cite journal | last1 = McManimen | first1 = Stephanie L. | author-link1 = Stephanie McManimen | last2 = Devendorf | first2 = Andrew R. | author-link2 = | last3 = Brown | first3 = Abigail A. | author-link3 = Abigail Brown | last4 = Moore | first4 = Billie C. | author-link4 = | last5 = Moore | first5 = James H. | author-link5 =| last6 = Jason | first6 = Leonard A. | author-link6 = Leonard Jason | title = Mortality in patients with myalgic encephalomyelitis and chronic fatigue syndrome| journal = Fatigue: Biomedicine, Health & Behavior | volume = 4 | issue = 4 | pages = 195-207 | url = https://doi.org/10.1080%2F21641846.2016.1236588| date = 2016| doi =10.1080/21641846.2016.1236588}}</ref> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5218818/ (Full Text)] *2016, Chronic fatigue syndrome in patient with ALK-positive anaplastic large cell lymphoma<ref name="Gauger2016"> https://ajbm.net/bm-publisher-5711-2/</ref> - [https://ajbm.net/bm-publisher-5711-2/ (Abstract)] *2012, Chronic fatigue syndrome and subsequent risk of cancer among elderly U.S. adults<ref name="Chang, 2012"> {{Cite journal | last1 = Chang | first1 = C.M. | author-link1 = | last2 = Warren | first2 = J.L. | author-link2 = | last3 = Engels | first3 = E.A. | author-link3 = | title = Chronic fatigue syndrome and subsequent risk of cancer among elderly U.S. adults| url=https://acsjournals.onlinelibrary.wiley.com/doi/10.1002/cncr.27612 | journal = Cancer | volume = 118 | issue = 23 | page = 5929–5936 | date = 2012| doi = 10.1002/cncr.27612}}</ref> - [https://acsjournals.onlinelibrary.wiley.com/doi/10.1002/cncr.27612 (Full text)] *2000, [[Chronic fatigue syndrome|Chronic Fatigue Syndrome]] and Cancer<ref name="Levine, 2000">{{Cite journal | last1 = Levine | first1 = Paul H. | author-link1 = Paul Levine | last2 = Pilkington | first2 =Deborah | author-link2 = | last3 = Strickland | first3 = Paula | author-link3 =| last4 = Peterson | first4 = Daniel | author-link4 = Daniel Peterson| title = Chronic Fatigue Syndrome and Cancer | url = https://doi.org/10.1300%2FJ092v07n01_04 | journal =Journal of Chronic Fatigue Syndrome | volume = 7 | issue = 1 | pages = 29-38| date = 2000 | pmid = | doi = 10.1300/J092v07n01_04}}</ref> - [http://dx.doi.org/10.1300/J092v07n01_04 (Abstract)] ==See also == *[[Cancer-related fatigue]] *[[Non-Hodgkin lymphoma]] *[[Causes of death]] *[[Rituximab]] *[[Cyclophosphamide]] *[[Ampligen]] ==Learn more == ==References== {{Reflist}} [[Category:Diagnoses]]
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