Brucella

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Brucella is a bacteria that spreads from animals to humans most commonly through ingesting a contaminated food product or direct contact with an infected animal. Human to human contact is very rare.[1] The incidence of confirmed infection in humans in the US hovers just over 100 cases total.[2] The incidence in other parts of the world is higher.[3]

Characteristics

Brucella is:

  • Gram-negative - does not retain a crystal violet stain used in the differentiation process
  • coccobacilli - has a shape intermediate between cocci (spherical bacteria) and bacilli (rod-shaped bacteria)
  • non-spore-forming
  • non-motile
  • aerobic - grows in the presence of oxygen
  • zoonotic - spreads to humans from animals

Classification

There are six species of Brucella. Three can cause serious disease in humans: Brucella abortus, Brucella melitensis and Brucella suis. One species, Brucella canis causes mild disease and the other two species have not affected humans.[4]

Brucellosis

The disease caused by a brucella infection is called brucellosis. It causes an acute febrile illness associated with rigors, sweats, malaise, anorexia, headache, pain in muscles, joint, and/or back, and fatigue. If untreated, it can potentially cause a debilitating chronic infection in humans with reoccurring fevers, arthritis, swelling of the testicle and scrotum area, swelling of the heart (endocarditis), neurologic symptoms (in up to 5% of all cases), chronic fatigue, depression, swelling of the liver and/or spleen.[5][6]

Risk for exposure

The people most at risk for acquiring a Brucella infection are people who[7]:

  • consume undercooked meat or unpasteurized milk products from an infected animal
  • slaughterhouse workers
  • meat-packing plant employees
  • veterinarians
  • hunters dressing an infected animal
  • laboratory workers who handle the bacteria
  • an infant breastfeeding from an infected mother

Treatment

Treatment is a combination of broad spectrum antibiotics.[8]

Lean more

See also

References

  1. "CDC - Home - Brucellosis". www.cdc.gov. March 8, 2019. Retrieved May 4, 2019.
  2. "Brucellosis Surveillance | References and Resources | Brucellosis | CDC". www.cdc.gov. October 9, 2018. Retrieved May 4, 2019.
  3. Rubach, M. P., Halliday, J. E. B., Cleaveland, S., & Crump, J. A. (2013). Brucellosis in low-income and middle-income countries. Current Opinion in Infectious Diseases, 26(5), 404–412. http://doi.org/10.1097/QCO.0b013e3283638104
  4. Alton GG, Forsyth JRL. Brucella. In: Baron S, editor. Medical Microbiology. 4th edition. Galveston (TX): University of Texas Medical Branch at Galveston; 1996. Chapter 28. Available from: https://www.ncbi.nlm.nih.gov/books/NBK8572/
  5. Rubach, M. P., Halliday, J. E. B., Cleaveland, S., & Crump, J. A. (2013). Brucellosis in low-income and middle-income countries. Current Opinion in Infectious Diseases, 26(5), 404–412. http://doi.org/10.1097/QCO.0b013e3283638104
  6. "Signs and Symptoms | Brucellosis | CDC". www.cdc.gov. October 9, 2018. Retrieved May 4, 2019.
  7. "Transmission | Brucellosis | CDC". www.cdc.gov. March 11, 2019. Retrieved May 4, 2019.
  8. Michael J. Corbel. (1997). Brucellosis: an Overview. Emerging Infectious Diseases. Vol. 3, No. 2, pp 213-221. DOI: 10.3201/eid0302.970219
  9. Michael J. Corbel. (1997). Brucellosis: an Overview. Emerging Infectious Diseases. Vol. 3, No. 2, pp 213-221. DOI: 10.3201/eid0302.970219