Anonymous
Not logged in
Talk
Contributions
Create account
Log in
Search
Editing
Brigitte Huber
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
Namespaces
Page
Discussion
More
More
Page actions
Read
Edit
Edit source
History
Warning:
You are not logged in. Your IP address will be publicly visible if you make any edits. If you
log in
or
create an account
, your edits will be attributed to your username, along with other benefits.
Anti-spam check. Do
not
fill this in!
[[File:Brigitte Huber.png|thumb|right|Source:Tufts University]] '''Brigitte Huber''', PhD, is a Professor of Integrative Physiology & Pathobiology, at the Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts.<ref>http://sackler.tufts.edu/Faculty-and-Research/Faculty-Profiles/Brigitte-Huber-Profile</ref> She has studied the presence of retrovirus HERV K-18 as a potential biomarker for those who develop [[ME/CFS|myalgic encephalomyelitis/chronic fatigue syndrome]] ([[ME/CFS]]) after a case of infectious [[mononucleosis]].<ref>http://www.investinme.org/IIMEC5.shtml</ref> HERV-K18 is one of many endogenous human retroviruses in the normal human genome. It can be activated in a variety of ways and affect the outcome of [[Epstein-Barr virus]] infection and influence autoimmune disease.<ref>http://sackler.tufts.edu/Faculty-and-Research/Faculty-Research-Pages/Brigitte-Huber</ref>Dr. Huber's research has shown that there are more HERV K-18 alleles in post-[[mononucleosis]] [[ME/CFS]] patients than in controls.<ref>http://www.investinme.org/IIMEC5.shtml</ref> In 2011, Dr. Huber and her lab associates were one of the groups who were unable to duplicate Dr. [[Judy Mikovits]]'s finding of the presence of [[XMRV]] in [[ME/CFS]] patients.<ref>Oakes B1, Qiu X, Levine S, Hackett J Jr, Huber BT. (2011). Failure to Detect XMRV-Specific Antibodies in the Plasma of CFS Patients Using Highly Sensitive Chemiluminescence Immunoassays. ''Advances in Virology, 2011'':854540. doi: 10.1155/2011/854540. Epub 2011 Jul 27. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/22312356</ref>In 2013, she and her lab associates were unable to show reactivation of [[human herpesvirus 6]] ([[Human herpesvirus 6]]) or [[human herpesvirus 7]] ([[HHV-7]]) in [[chronic fatigue syndrome]].<ref>Oakes B, Hoagland-Henefield M, Komaroff AL, Erickson JL, Huber BT. (2013). Human endogenous retrovirus-K18 superantigen expression and human herpesvirus-6 and human herpesvirus-7 viral loads in chronic fatigue patients. ''Clinical Infectious Disease,56'' (10):1394-400. doi: 10.1093/cid/cit086. Epub 2013 Feb 13. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/23408682</ref> ==Education== *BA, Biology, University of Zurich *MSc, Pharmacology, University of Basel *PhD, Immunogenetics, University of London *Postdoctoral Training, Harvard Medical School ==Talks and interviews== *2010, [http://www.investinme.org/IIMEC5.shtml#agenda Speaker at the 5th [[Invest in ME International ME Conference]] on ''Presence of Retrovirus as a Biomarker for ME/CFS''] [http://www.investinme.org/IIMEC5.shtml#dvd DVD available] ==Studies== *2001, [[Epstein-Barr virus]] transactivates the human endogenous retrovirus HERV-K18 that encodes a superantigen.<ref>Sutkowski N1, Conrad B, Thorley-Lawson DA, Huber BT. (2001). Epstein-Barr virus transactivates the human endogenous retrovirus HERV-K18 that encodes a superantigen. ''Immunity, 15'' (4):579-89</ref> [https://www.cell.com/immunity/fulltext/S1074-7613(01)00210-2?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761301002102%3Fshowall%3Dtrue (Full Text)] *2011, Failure to Detect [[XMRV]]-Specific Antibodies in the Plasma of CFS Patients Using Highly Sensitive Chemiluminescence Immunoassays.<ref>Oakes B, Qiu X, Levine S, Hackett J Jr, Huber BT. (2011). Failure to Detect XMRV-Specific Antibodies in the Plasma of CFS Patients Using Highly Sensitive Chemiluminescence Immunoassays. ''Advances in Virology,2011'':854540. doi: 10.1155/2011/854540</ref> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265317/ (Full text)] *2013, Human endogenous retrovirus-K18 superantigen expression and human [[Human herpesvirus 6|herpesvirus-6]] and [[Human herpesvirus 7|human herpesvirus-7]] viral loads in chronic fatigue patients<ref>Oakes B, Hoagland-Henefield M, Komaroff AL, Erickson JL, Huber BT. (2013). Human endogenous retrovirus-K18 superantigen expression and human herpesvirus-6 and human herpesvirus-7 viral loads in chronic fatigue patients. ''Clinical Infectious Disease, 56'' (10):1394-400. doi: 10.1093/cid/cit086</ref> [https://academic.oup.com/cid/article/56/10/1394/406518 (Full Text)] ==Online presence== ==See also== ==Learn more== *[https://www.scientificamerican.com/article/chronic-fatigue-syndrome-retrovirus/ ==References== {{Reflist}} [[Category:Researchers]] [[Category:US researchers]]
Summary:
Please make sure your edits are consistent with
MEpedia's guidelines
.
By saving changes, you agree to the
Terms of use
, and you irrevocably agree to release your contribution under the
CC BY-SA 3.0 License
and the
GFDL
. You agree that a hyperlink or URL is sufficient attribution under the Creative Commons license.
Cancel
Editing help
(opens in new window)
Templates used on this page:
Template:Main other
(
edit
)
Template:Reflist
(
edit
)
Module:Check for unknown parameters
(
edit
)
Navigation
Navigation
Skip to content
Main page
Browse
Become an editor
Random page
Popular pages
Abbreviations
Glossary
About MEpedia
Links for editors
Contents
Guidelines
Recent changes
Pages in need
Search
Help
Wiki tools
Wiki tools
Special pages
Page tools
Page tools
User page tools
More
What links here
Related changes
Page information
Page logs