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Brett Lidbury
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[[File:Brett Lidbury.png|200px|thumb|right]] '''Brett A. Lidbury''', B.Sc, B.Sc (Hons) (Newcastle), PhD (ANU), FFSc (RCPA), is an Associate Professor with the National Centre for Epidemiology and Population Health (Research School of Population Health), College of Health and Medicine at the Australian National University. His areas of expertise are medical virology, innate immunity, and biostatistics. Research interests include improving the efficacy of diagnostic pathology and [[Diagnostic biomarker|biomarker]] pattern discovery, particularly in relation to [[ME/CFS]] and infectious diseases. Earlier research activity was interested in [[Ross River virus]] (RRV) pathogenesis, which as an Australian viral suspect in long-term fatigue, lead to current endeavors for chronic fatigue syndrome/myalgic encephalomyelitis. His work is entirely focused on human biology and pathology, without the requirement to develop an animal model.<ref>{{Cite web | url = https://researchers.anu.edu.au/researchers/lidbury-ba | title = Associate Professor Brett Lidbury | last = | first = | author-link = | date = | website = researchers.anu.edu.au|language=en-US|archive-url=|archive-date=|url-status= | access-date = 2019-09-25}}</ref> ==ME/CFS research== Dr Lidbury and his colleagues are conducting Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) studies that are ongoing with research participants recruited and assessed by CFS Discovery in Melbourne (Donvale, VIC 3111), in collaboration with the Hudson Research Institute, Paranta Biosciences, [[Bio21 Molecular Science and Biotechnology Institute|Bio21 Institute]] (University of Melbourne), La Trobe University and Universidad del Rosario, Bogota (School of Medicine and Health Sciences). Via these collaborations we are gathering data on potential immune serum markers (see [[Activin B]]), mitochondrial function and [[metabolomics]], as well as genetics, with the ANU group applying computational methods, for example machine learning, to interrogate these results as a systems biology investigation. A strength at the ANU is also the assessment of pathology and clinical data to increase diagnostic prediction, while developing rules to simplify decision-making for patient assessment. The [[ME/CFS]] project for the validation of Activin markers is funded by the Judith Jane Mason & Harold Stannett Williams Memorial Foundation, and projects concerning genetic analyses are funded by [[ME Research UK]].<ref>{{Cite web | url = http://www.meresearch.org.uk/ | title = ME Research UK {{!}} Energising ME research|language=en-US | access-date = 2019-09-25}}</ref> ==Awards== * Nominee for 2016 ACT Scientist of the Year<ref>{{Cite web | url = https://meaustralia.net/2016/07/11/me-microbiome-scientist-nominated-as-act-scientist-of-the-year/ | title = ME microbiome scientist nominated as ACT Scientist of the Year | last = Australia | first = ~ ME news | date = 2016-07-11 | website = ME Australia|language=en-US | access-date = 2019-09-25}}</ref> * Fellowship to the Faculty of Science, The Royal College of Pathologists of Australasia. ==Notable studies== *2014, Comorbidity of [[postural orthostatic tachycardia syndrome]] and [[chronic fatigue syndrome]] in an Australian cohort<ref>{{Cite journal | last = Reynolds | first = G.K. | author-link = | last2 = Lewis | first2 =D.P. | author-link2 = Donald Lewis | last3 = Richardson | first3 = A.M. | author-link3 = | last4 = Lidbury | first4 = B.A. | author-link4 = Brett Lidbury | date = Apr 2014 | title = Comorbidity of postural orthostatic tachycardia syndrome and chronic fatigue syndrome in an Australian cohort | url = http://doi.wiley.com/10.1111/joim.12161 | journal = Journal of Internal Medicine|language=en | volume = 275 | issue = 4 | pages = 409β417|doi=10.1111/joim.12161|pmc=|pmid=|access-date=|quote=|via=}}</ref> - [https://onlinelibrary.wiley.com/doi/full/10.1111/joim.12161 (Full text)] *2017, Activin B is a novel [[Diagnostic biomarker|biomarker]] for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) diagnosis: a cross sectional study<ref>{{Citation | last1 = Lidbury | first1 = Brett | author-link = Brett Lidbury | last2 = Badia | first2 = Kita | author-link2 = | last3 = Lewis | first3 = Donald | author-link3 = Donald Lewis | last4 = Hayward | first4 = Susan | author-link4 = | last5 = Ludlow | first5 = Helen | author-link5 = | last6 = Hedger | first6 = Mark | author-link6 = | last7 = de Kretser | first7 = David | author-link8 = | title = Activin B is a novel biomarker for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) diagnosis: a cross sectional study|journal = Journal of Translational Medicine | volume = | issue = | page = | date = 2017 | pmid= |doi=10.1186/s12967-017-1161-4}}</ref> - [https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-017-1161-4 (Full text)] *2018, Weighting of [[orthostatic intolerance]] time measurements with standing difficulty score stratifies [[ME/CFS]] symptom severity and analyte detection<ref>{{Cite journal | last = Richardson | first = Alice M. | author-link = | last2 = Lewis | first2 = Don P. | author-link2 = Donald Lewis | last3 = Kita | first3 = Badia | author-link3 = | last4 = Ludlow | first4 = Helen | author-link4 = | last5 = Groome | first5 = Nigel P. | author-link5 = | last6 = Hedger | first6 = Mark P. | author-link6 = | last7 = de Kretser | first7 = David M. | last8 = Lidbury | first8 = Brett A. | author-link8 = Brett Lidbury | date = Dec 2018 | title = Weighting of orthostatic intolerance time measurements with standing difficulty score stratifies ME/CFS symptom severity and analyte detection | url =https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-018-1473-z | journal = Journal of Translational Medicine|language=en | volume = 16 | issue = 1 | pages = 97|doi=10.1186/s12967-018-1473-z|issn=1479-5876|pmc=5898049|pmid=29650052|access-date=|quote=|via=}}</ref> - [https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-018-1473-z (Full text)] *2019, An Isolated Complex V Inefficiency and Dysregulated Mitochondrial Function in Immortalized Lymphocytes from ME/CFS Patients<ref>{{Cite journal | last = Missailidis | first = Daniel | author-link = | last2 = Annesley | first2 = Sarah | author-link2 = | last3 = Allan | first3 = Claire | author-link3 = | last4 = Sanislav | first4 = Oana | author-link4 = | last5 = Lidbury | first5 = Brett | author-link5 = Brett Lidbury | last6 = Lewis | first6 = Don | author-link6 = Donald Lewis | last7 = Fisher | first7 = Paul | author-link8 = Paul Fisher | date = 2019-09-04 | title = An Isolated Complex V Inefficiency and Dysregulated Mitochondrial Function in Immortalized Lymphocytes from ME/CFS Patients |url =http://www.preprints.org/manuscript/201909.0043/v1 | journal = Preprints | volume = | issue = | pages = |doi=10.20944/preprints201909.0043.v1|pmc=|pmid=|access-date=|quote=|via=}}</ref> - [https://www.preprints.org/manuscript/201909.0043/v1 (Abstract)] *2020, Biomedical Insights That Inform the Diagnosis of ME/CFS<ref>{{Cite journal | last = Lidbury | first = Brett A. | author-link = Brett Lidbury | last2 = Fisher | first2 = Paul R. | author-link2 = Paul Fisher | date = 2020-02-08 | title = Biomedical Insights That Inform the Diagnosis of ME/CFS | url = https://www.mdpi.com/2075-4418/10/2/92 | journal = Diagnostics|language=en | volume = 10 | issue = 2 | pages = 92|doi=10.3390/diagnostics10020092|issn=2075-4418|pmc=|pmid=|access-date=|quote=|via=}}</ref> - [https://www.mdpi.com/2075-4418/10/2/92/htm (Full Text)] ==Talks and interviews== * 13 Mar 2019, ''[https://mecfsconference.org.au/videos/brett-lidbury/ Rethinking Diagnostic Reference Intervals for ME/CFS via Machine Learning & the Utility of Activin B to Assess Symptom Severity]'' given at the [[International Research Symposium - Emerge Australia|International Research Symposium]], Geelong, Australia, sponsored by [[Emerge Australia]] ==Online presence== *[https://www.ncbi.nlm.nih.gov/pubmed/?term=Lidbury%20BA%5BAuthor%5D&cauthor=true&cauthor_uid=29650052 PubMed] *[http://rsph.anu.edu.au/people/academics/associate-professor-brett-lidbury Australian National University faculty bio] ==See also== *[[Activin B]] *[[Australia]] *[[Diagnostic biomarker]] ==Learn more== *2016, [http://www.meaction.net/2016/04/05/meet-the-scientists-dr-brett-lidbury/ Meet the scientists - Dr Brett Lidbury] *2018, [https://meaustralia.net/2018/08/06/how-much-can-people-with-me-stand/ How much can people with ME stand?] ==References== {{reflist}} [[Category:Researchers]] [[Category:Australia researchers]]
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