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Brains of People With Chronic Fatigue Syndrome Offer Clues About Disorder - New York Times: Well (2014)
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== Brain imaging studies mentioned in article == *2014, The [[Stanford ME/CFS Initiative]], directed by Dr. [[Jose Montoya]] and working with Dr. [[Michael Zeineh]] and colleagues, studied the brains of patients with [[chronic fatigue syndrome]] (CFS) and healthy people and found distinct differences between the two groups. Radiology researchers have discovered that the brains of patients with [[Chronic fatigue syndrome|CFS]] have diminished white matter and white matter abnormalities in the right hemisphere.<ref>{{Cite journal | last = Zeineh | first = Michael M. | author-link = Michael Zeineh | last2 = Kang | first2 = James | author-link2 = | last3 = Atlas | first3 = Scott W. | author-link3 = | last4 = Raman | first4 = Mira M. | author-link4 = | last5 = Reiss | first5 = Allan L. | author-link5 = | last6 = Norris | first6 = Jane L. | author-link6 = Jane Norris | last7 = Valencia | first7 = Ian | author-link8 = Ian Valencia | last8 = Montoya | first8 = Jose G. | author-link9 = Jose Montoya | date = Feb 2015 | title = Right Arcuate Fasciculus Abnormality in Chronic Fatigue Syndrome | url =http://pubs.rsna.org/doi/10.1148/radiol.14141079 | journal = Radiology|language=en | volume = 274 | issue = 2 | pages = 517β526|doi=10.1148/radiol.14141079|issn=0033-8419|pmc=|pmid=|access-date=|quote=|via=}}</ref><ref>{{Cite web | url = http://med.stanford.edu/news/all-news/2014/10/study-finds-brain-abnormalities-in-chronic-fatigue-patients.html | title = Study finds brain abnormalities in chronic fatigue patients | last = Goldman | first = Bruce | author-link = | date = 2014-10-28 | website = Standford University News Center|language=en|archive-url=|archive-date=|url-status= | access-date = 2020-01-10}}</ref><ref name="Tuller20141124NYT" /> *2014, A Japanese [[PET scan]] study looked at [[neuroinflammation]] in 9 patients with ME/CFS and 10 controls. They measured a protein expressed by activated [[microglia]], and found that values in the cingulate cortex, [[hippocampus]], [[amygdala]], thalamus, midbrain, and pons were 45%β199% higher in ME/CFS patients than in healthy controls. The values in the amygdala, thalamus, and midbrain positively correlated with cognitive impairment score, the values in the cingulate cortex and thalamus positively correlated with pain score, and the value in the hippocampus positively correlated with depression score.<ref name="Nakatomi2014" /><ref name="Tuller20141124NYT" />
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