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Brain-derived neurotrophic factor
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{{stub}} '''Brain-derived neurotrophic factor''' or '''BDNF''' is a protein in the neurotrophic family.<ref name="PMC2504526">{{Cite journal | last = Binder | first = Devin K. | author-link = | last2 = Scharfman | first2 = Helen E. | author-link2 = | date = Sep 2004 | title = Brain-derived Neurotrophic Factor |url =https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2504526/ | journal = Growth factors (Chur, Switzerland) | volume = 22 | issue = 3 | pages = 123β131|doi=10.1080/08977190410001723308|issn=0897-7194|pmc=2504526|pmid=15518235|access-date=|quote=|via=}}</ref> The name BDNF is also used to refer to the related gene that expresses BDNF.<ref name="PMC2504526" /> ==Function== ==ME/CFS== ==Notable studies == *2015, Brain-derived neurotrophic factor concentration may not be depressed in chronic fatigue syndrome<ref name="Patrick2015">{{Cite journal | title = Brain-derived neurotrophic factor concentration may not be depressed in chronic fatigue syndrome | date = 2015-04-03 | url = https://doi.org/10.1080/21641846.2015.1024004|journal = Fatigue: Biomedicine, Health & Behavior | volume = 3 | issue = 2 | pages = 122β125 | last = Patrick | first = David M. | last2 = Miller | first2 = Ruth R. | last3 = Steiner | first3 = Theodore | last4 = Gardy | first4 = Jennifer L. | last5 = Parker | first5 = Shoshana M. | last6 = Tang | first6 = Patrick|doi=10.1080/21641846.2015.1024004|issn=2164-1846}}</ref> - [https://www.tandfonline.com/doi/full/10.1080/21641846.2015.1024004 (Abstract)] *2015, Exercise and caffeine improve sustained attention following fatigue independent of fitness status<ref name="Kumar2015">{{Cite journal | title = Exercise and caffeine improve sustained attention following fatigue independent of fitness status | date = 2015-04-03 | url = https://doi.org/10.1080/21641846.2015.1027553|journal = Fatigue: Biomedicine, Health & Behavior | volume = 3 | issue = 2 | pages = 104β121 | last = Kumar | first = Namrita | last2 = Wheaton | first2 = Lewis A. | last3 = Snow | first3 = Teresa K. | last4 = Millard-Stafford | first4 = Melinda|doi=10.1080/21641846.2015.1027553|issn=2164-1846}}</ref> - [https://web.archive.org/web/20190225113231id_/http://pdfs.semanticscholar.org/61f9/b87e28a4902e1cc01250fca88dd39221256f.pdf (Full text)] *2015, Brain-derived neurotrophic factor (BDNF) as a driving force behind neuroplasticity in neuropathic and central sensitization pain: a new therapeutic target?<ref name="Nijs2015">{{Cite journal | title = Brain-derived neurotrophic factor as a driving force behind neuroplasticity in neuropathic and central sensitization pain: a new therapeutic target? | date = Apr 2015 | url = https://pubmed.ncbi.nlm.nih.gov/25519921/ | journal = Expert Opinion on Therapeutic Targets | volume = 19 | issue = 4 | pages = 565β576 | last = Nijs | first = Jo | author-link = Jo Nijs | last2 = Meeus | first2 = Mira | author-link2 = Mira Meeus | last3 = Versijpt | first3 = Jan | author-link3 = | last4 = Moens | first4 = Maarten | author-link4 = | last5 = Bos | first5 = Inge | author-link5 = | last6 = Knaepen | first6 = Kristel | author-link6 = | last7 = Meeusen | first7 = Romain|doi=10.1517/14728222.2014.994506|pmc=|pmid=25519921|access-date=|issn=1744-7631|quote=|via=}}</ref> - [http://www.ncbi.nlm.nih.gov/pubmed/25519921 (Full text)] *2020, DNA Methylation and Brain-Derived Neurotrophic Factor Expression Account for Symptoms and Widespread Hyperalgesia in Patients With Chronic Fatigue Syndrome and Comorbid Fibromyalgia<ref name="Polli2020">{{Cite journal | last = Polli | first = Andrea | author-link = Andrea Polli | last2 = Ghosh | first2 = Manosij | author-link2 = | last3 = Bakusic | first3 = Jelena | author-link3 = | last4 = Ickmans | first4 = Kelly | author-link4 = Kelly Ickmans | last5 = Monteyne | first5 = Dora | author-link5 = | last6 = Velkeniers | first6 = Brigitte | author-link6 = | last7 = Bekaert | first7 = Bram | last8 = Godderis | first8 = Lode | author-link8 = Godderis Lode | last9 = Nijs | first9 = Jo | author-link9 = Jo Nijs | date = Nov 2020 | title = DNA Methylation and Brain-Derived Neurotrophic Factor Expression Account for Symptoms and Widespread Hyperalgesia in Patients With Chronic Fatigue Syndrome and Comorbid Fibromyalgia | url = https://pubmed.ncbi.nlm.nih.gov/32562379/ | journal = Arthritis & Rheumatology (Hoboken, N.J.) | volume = 72 | issue = 11 | pages = 1936β1944|doi=10.1002/art.41405|issn=2326-5205|pmc=|pmid=32562379|access-date=|quote=|via=}}</ref> - [https://pubmed.ncbi.nlm.nih.gov/32562379/ (Abstract)] ==See also == *[[Central sensitization]] *[[Allodynia]] (pain on touch) ==Learn more == *[https://www.meresearch.org.uk/research/epigenetic-modification-of-bdnf-and-hdacs/ Epigenetic modification of BDNF and HDAC in pain and post-exertional malaise] - ME Research UK *[https://www.meresearch.org.uk/research/bdnf-epigenetics/ Epigenetics of the BDNF gene and its relevance for pain: an exploratory study] - ME Research UK *[http://www.paininmotion.be/EN/news-2015-BDNF-proteiin-structure.html Brain-derived neurotrophic factor (BDNF) as a driving force behind central sensitization pain: a new therapeutic target?] - Jo Nijs (2015), Pain in Motion ==References == {{Reflist}} [[Category:Biochemistry and cell biology]] [[Category:Growth factors]] [[Category:Genes]] [[Category:Proteins]]
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