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===T2 Hyperintensities in MRI=== {{bookmark|T2 hyperintensity}} [[File:T2hyperintensitiesVRS.jpg|400px|thumb|MRI image with small white T2 hyperintensities, which are labelled as "Virchow-Robin spaces". Use allowed for educational purposes, courtesy of radiologyassistant.nl]] Possible white matter abnormalities of unknown etiology are found on MRIs of some [[ME/CFS]] patients.<ref name="Shan2016" /><ref name="Natelson1993">{{Cite journal | last = Natelson | first = B.H. | last2 = Cohen | first2 = J.M. | last3 = Brassloff | first3 = I. | last4 = Lee | first4 = H.J. | date = 1993-12-15 | title = A controlled study of brain magnetic resonance imaging in patients with the chronic fatigue syndrome | url =https://www.ncbi.nlm.nih.gov/pubmed/8138812 | journal = Journal of the Neurological Sciences | volume = 120 | issue = 2 | pages = 213β217|doi=10.1016/0022-510x(93)90276-5|issn=0022-510X|pmid=8138812|pmc=|quote= | author-link = Benjamin Natelson | author-link2 = |access-date=|via=}}</ref><ref name="Lange1999">{{Cite journal | last = Lange | first = G. | last2 = DeLuca | first2 = J. | last3 = Maldjian | first3 = J.A. | last4 = Lee | first4 = H. | last5 = Tiersky | first5 = L.A. |last6 = Natelson | first6 = B.H. | date = 1999-12-01 | title = Brain MRI abnormalities exist in a subset of patients with chronic fatigue syndrome | url =https://www.ncbi.nlm.nih.gov/pubmed/10567042 | journal = Journal of the Neurological Sciences | volume = 171 | issue = 1 | pages = 3β7|doi=10.1016/s0022-510x(99)00243-9|issn=0022-510X|pmid=10567042}}</ref> White matter abnormalities identified by T2 hyperintensities might indicate lesions or abnormally dilated perivascular spaces (also known as Virchow-Robin spaces).<ref>{{Cite journal | last = Kwee | first = Robert M. | last2 = Kwee | first2 = Thomas C. | date = 2007-07-01 | title = Virchow-Robin Spaces at MR Imaging | url =https://pubs.rsna.org/doi/full/10.1148/rg.274065722 | journal = RadioGraphics | volume = 27 | issue = 4 | pages = 1071β1086|doi=10.1148/rg.274065722|issn=0271-5333}}</ref> * 1993, A comparison of brain MRI scans from 52 CFS patients and 52 controls found that 27% of CFS patients had findings considered abnormal, while only 2% of controls had findings considered abnormal. Abnormalities included T2 hyperintensities and ventricular enlargement.<ref name="Natelson1993" /> * 1999, A comparison of brain MRI scans from 39 CFS patients and 19 controls found that the 21 CFS patients who did not have a psychiatric diagnosis had significantly more T2 hyperintensities, compared to either controls or the 18 CFS patients with a psychiatric diagnosis.<ref name="Lange1999" /> Since T2 hyperintensities are found in many different [[:Category:Neurological diseases and disorders|neurological conditions]], some neurologists consider them to be diagnostically insignificant. Others point out that perhaps they should not be ignored, as they are correlated with cognitive disability and poor motor function.<ref>{{Cite journal | last = Jeong | first = Eun Hye | last2 = Lee | first2 = Yong Joo | last3 = Kim | first3 = Sang Joon | last4 = Lee | first4 = Jae-Hong | date = 2015 | title = Is the Severity of Dilated Virchow-Robin Spaces Associated with Cognitive Dysfunction? | url = http://dx.doi.org/10.12779/dnd.2015.14.3.114 | journal = Dementia and Neurocognitive Disorders | volume = 14 | issue = 3 | pages = 114|doi=10.12779/dnd.2015.14.3.114|issn=1738-1495}}</ref><ref>{{Cite journal | last = Sachdev | first = P.S. | last2 = Wen | first2 = W. | last3 = Christensen | first3 = H. | last4 = Jorm | first4 = A.F. | date = 2005-03-01 | title = White matter hyperintensities are related to physical disability and poor motor function | url =https://jnnp.bmj.com/content/76/3/362 | journal = Journal of Neurology, Neurosurgery & Psychiatry|language=en | volume = 76 | issue = 3 | pages = 362β367|doi=10.1136/jnnp.2004.042945|issn=0022-3050|pmid=15716527}}</ref><ref>{{Cite journal | last = Paradise | first = Matthew | last2 = Crawford | first2 = John D. | last3 = Lam | first3 = Ben C.P. | last4 = Wen | first4 = Wei | last5 = Kochan | first5 = Nicole A. | last6 = Makkar | first6 = Steve | last7 = Dawes | first7 = Laughlin | last8 = Trollor | first8 = Julian | last9 = Draper | first9 = Brian | date = 2021-01-27 | title = The Association of Dilated Perivascular Spaces with Cognitive Decline and Incident Dementia | url = https://n.neurology.org/content/early/2021/01/27/WNL.0000000000011537 | journal = Neurology|language=en|doi=10.1212/WNL.0000000000011537|issn=0028-3878|pmid=33504642}}</ref>
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