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=== Metabolism === A 2003 study of cerebral [[glucose]] metabolism in 26 patients with [[chronic fatigue syndrome]] via 18-fluorodeoxyglucose positron emission tomography (FDG-PET) found evidence of hypometabolism (reduced glucose consumption) in approximately half of patients.<ref>{{Cite journal | title = Observer independent analysis of cerebral glucose metabolism in patients with chronic fatigue syndrome | url =https://jnnp.bmj.com/content/74/7/922 | journal = Journal of Neurology, Neurosurgery & Psychiatry | date = 2003-07-01|issn=0022-3050|pmid=12810781 | pages = 922–928 | volume = 74 | issue = 7|doi=10.1136/jnnp.74.7.922|language=en | first = P. | last = Bartenstein | first2 = U.T. | last2 = Egle | first3 = M. | last3 = Schreckenberger | first4 = J. | last4 = Hardt | first5 = W.A. | last5 = Nix | first6 = T. | last6 = Siessmeier}}</ref> A 1998 PET study also found evidence of reduced metabolism in 18 patients.<ref>{{Cite journal | last = Tirelli | first = Umberto | last2 = Chierichetti | first2 = Franca | last3 = Tavio | first3 = Marcello | last4 = Simonelli | first4 = Cecilia | last5 = Bianchin | first5 = Gianluigi | last6 = Zanco | first6 = Pierluigi | last7 = Ferlin | first7 = Giorgio | date = 1998-09-28 | title = Brain positron emission tomography (PET) in chronic fatigue syndrome: preliminary data | url = http://www.sciencedirect.com/science/article/pii/S000293439800179X | journal = The American Journal of Medicine | volume = 105 | issue = 3, Supplement 1 | pages = 54S–58S|doi=10.1016/S0002-9343(98)00179-X|issn=0002-9343}}</ref> Patients with ME/CFS have also been found to have lower brain glutathione<ref name="Natelson, 2017" /> and higher brain ventricular lactate.<ref name="Natelson, 2017" /> Abnormal distribution of [[Carnitine|acetyl-L-carnitine]] uptake, which is one of the biochemical markers of chronic fatigue syndrome, in the prefrontal cortex.{{Citation needed|reason=clarify}}<ref name="Okada2004" /> {{See also|Mitochondria dysfunction|||||}}
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