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=== Anatomical changes === Significant changes in white and gray matter volumes have frequently been found in patients with ME/CFS but no consistent pattern has been found.<ref name="Shan2016" /><ref name="Goldman20141028">{{Cite journal | last1 = Goldman | first1 = Bruce | author-link1 = | title = Study finds brain abnormalities in chronic fatigue patients | journal = Stanford Medicine News Center | date = 2014-10-28 | url = http://med.stanford.edu/news/all-news/2014/10/study-finds-brain-abnormalities-in-chronic-fatigue-patients.html }}</ref><ref name="Zeineh2014">{{Cite journal | last1 = Zeineh | first1 = Michael M | author-link1 = Michael Zeineh | last2 = Kang | first2 = James | author-link2 = James Kang | last3 = Atlas | first3 = Scott W | author-link3 = Scott Atlas | last4 = Raman | first4 = Mira M | author-link4 = Mira Raman | last5 = Reiss | first5 = Allan L | author-link5 = Allan Reiss | last6 = Norris | first6 = Jane L | author-link6 = Jane Norris | last7 = Valencia | first7 = Ian | author-link8 = Ian Valencia | last8 = Montoya | first8 = Jose G | author-link8 = Jose Montoya | title = Right Arcuate Fasciculus Abnormality in Chronic Fatigue Syndrome | journal = Radiology | volume = 274 | issue = 2| pages = 517β526 | date = 2014-10-29 | doi = 10.1148/radiol.14141079 | url = http://pubs.rsna.org/doi/abs/10.1148/radiol.14141079 }}</ref><ref name="Puri, 2012">{{Cite journal | last1 = Puri | first1 = BK | author-link1 = Basant Puri | last2 = Jakeman | first2 =PM | author-link2 = | last3 = Agour | first3 = M | author-link3 = | last4 = Gunatilake | first4 = KDR | author-link4 = | last5 = Fernando | first5 = KAC | author-link5 = | last6 = Gurusinghe | first6 = AI | author-link6 = | last7 = Treasaden | first7 = IH | author-link7 = | last8 = Waldman | first8 = AD | author-link8 = | last9 = Gishen | first9 = P | author-link9 = | title = Regional grey and white matter volumetric changes in myalgic encephalomyelitis (chronic fatigue syndrome): a voxel-based morphometry 3 T MRI study | journal = British Journal of Radiology | volume = 85 | issue = 1015 | page = e270-3 | date = 2012 | pmid = | doi = 10.1259/bjr/93889091 }}</ref> {| class="wikitable" !Year !Authors !N !Criteria !Findings !Ref |- |2004 |Okada, et al |16 | |Reduced gray-matter volume in the bilateral prefrontal cortex. Volume reduction in the right prefrontal cortex correlated with fatigue severity. |<ref name="Okada2004">{{Cite journal | last = Okada | first = Tomohisa | last2 = Tanaka | first2 = Masaaki | last3 = Kuratsune | first3 = Hirohiko | last4 = Watanabe | first4 = Yasuyoshi | last5 = Sadato | first5 = Norihiro | date = 2004-10-04 | title = Mechanisms underlying fatigue: a voxel-based morphometric study of chronic fatigue syndrome | url =https://doi.org/10.1186/1471-2377-4-14 | journal = BMC Neurology | volume = 4 | issue = 1 | pages = 14|doi=10.1186/1471-2377-4-14|issn=1471-2377|pmc=524491|pmid=15461817}}</ref> |- |2016 |Shan, et al | |Fukuda & CCC |Decreases inΒ [[white matter]],Β [[gray matter]] and blood volume deficits |<ref name="Shan2016" /> |- |2012 |Basant Puri, et al | | |Reduced grey matter volume in the occipital lobes, the right angular gyrus and the posterior division of the left parahippocampal gyrus. |<ref name="Puri, 2012" /> |- |2014 |Zeineh, et al | | |Diminished white matter, white matter abnormalities in the right hemisphere. |<ref name="Zeineh2014" /> |}
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