Borna disease virus

The Borna disease virus (BDV) is in the order of Mononegavirales. Humans can contract the bornavirus and it is considered to be a Zoonotic.

Notable studies

• 1999, Borna Disease Virus Proteins in Patients with CFS

  "Summary - Bornavirus is a member of a newly recognized virus family, Bornaviridae, and is neurotropic for a wide range of animal species, including birds, rodents, horses, and humans. Although little is known about its mode of transmission and it has not been clearly linked to any human disease, an association between borna viruses and neuro-psychiatric disorders has been suggested. Several researchers have also isolated this organism from patients who meet the clinical criteria for the Chronic Fatigue Syndrome (CFS). However, due to non-standardization of assay protocols, lack of a large study population and the possibility of contamination in certain laboratory settings, the true prevalence of Bornaviral proteins and their possible role in the pathogenesis of at least a subgroup of CFS patients remains undefined. We analyzed the serum immune reactivity to Borna Disease Virus (BDV) in 77 CFS patients and in 33 healthy normal controls using an ELISA based assay of 3 different recombinant BDV proteins. Of the 6 samples that displayed immunoreactivity to 2 or more BDV proteins, 5 were from patients (83.3%). Two samples, both from CFS patients, displayed immunoreactivity to 3 BDV proteins."

• 1999 Swedish study, Absence of evidence of Borna disease virus infection in Swedish patients with Chronic Fatigue Syndrome.
• 1999 Japanese study, Borna disease virus infection in two family clusters of patients with chronic fatigue syndrome.
• 1997 Japanese study, Demonstration on Borna disease virus in patients with chronic fatigue syndrome.
• 1996 Japanese study, Possible correlation between Borna disease virus infection and Japanese patients with chronic fatigue syndrome.
• 1996 Japanese study, Demonstration of Borna disease virus RNA in peripheral blood mononuclear cells derived from Japanese patients with chronic fatigue syndrome.

assay 1. (verb) analysis (as of an ore or drug) to determine the presence, absence, or quantity of one or more components. 2. (noun) In biochemistry, any laboratory protocol used to test a sample for one or more qualities.

serum The clear yellowish fluid that remains from blood plasma after clotting factors have been removed by clot formation. (Blood plasma is simply blood that has had its blood cells removed.)