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===Plasma and impaired metabolic in ME/CFS === A biomarker being investigated for [[ME/CFS]] found that plasma together with several types of white blood cells, known as collectively as [[Peripheral blood mononuclear cell|peripheral blood mononuclear cells]] (PBMCs), reacted differently to plasma and white blood cells from healthy controls when put under a salt stress test designed to mimic [[post-exertional malaise]]. The PBMCs from the blood of ME/CFS patients was then put in plasma from healthy controls, which significantly improved their response to the biological stress.<ref name="Davis2019" /><br> The original hypothesis being tested was that "extensive consumption and potential depletion of [[ATP]], a high-energy [[metabolite]]" would be found in the blood of [[ME/CFS]] patients, and this was confirmed, along with finding a unique metabolic signature that correctly identified all patients and no healthy controls.<ref name="Davis2019" />
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