Anonymous
Not logged in
Talk
Contributions
Create account
Log in
Search
Editing
Autophagy related gene 13
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
Namespaces
Page
Discussion
More
More
Page actions
Read
Edit
Edit source
History
Warning:
You are not logged in. Your IP address will be publicly visible if you make any edits. If you
log in
or
create an account
, your edits will be attributed to your username, along with other benefits.
Anti-spam check. Do
not
fill this in!
{{stub}} '''Autophagy Related 13''' or '''ATG13''' is a gene that is involved in controlling autophagy.<ref name="genecards">{{Cite web | access-date=2022-11-05| url = https://www.genecards.org/cgi-bin/carddisp.pl?gene=ATG13 | title = ATG13 Gene card | website = Gene cards}}</ref> ==Function == ==ME/CFS== In May 2022, Simmaron Research announced that they were inserting several human genes including ATG13 into mice in order to research [[post-exertional malaise]] and [[fatigue]].<ref name="SimmMay2022">{{Cite web |access-date=November 5, 2022|url = https://www.simmaronresearch.com/blog/seeing-mecfs-creating-the-first-mouse-models-for-the-disease | title = Seeing ME/CFS: Creating the First Mouse Models for the Disease | website = Simmaron Research | date = May 10, 2022}}</ref> ATG13 activates the myokines [[interleukin 6]] (IL-6) and [[Regulated upon activation, normally T-expressed, and presumably secreted]] (RANTES).<ref name="SimmMay2022"/> ==Notable studies == * 2021, Molecular evidence of autophagy impairment as serum level of ATG13 is elevated in patients with myalgic encephalomyelitis and chronic fatigue syndrome: two independent case-control studies<ref name="Roy2021">{{Cite web | url = https://www.researchsquare.com/ | title = Molecular evidence of autophagy impairment as serum level of ATG13 is elevated in patients with myalgic encephalomyelitis and chronic fatigue syndrome: two independent case-control studies | last = Avik | first = R | author-link = Avik Roy | last2 = Gottschalk | first2 = Carl G | author-link2 = Gunnar Gottschalk | last3 = Peterson | first3 = Daniel | author-link3 = Daniel Peterson | last4 = Knox | first4 = K | author-link4 = | last5 = Maynard | first5 = M | author-link5 = | last6 = Whelan | first6 = RJ | author-link6 = | date = 2021-09-29 | website = Researchsquare | doi = 10.21203/rs.3.rs-925403/v1| url-status= |access-date=2022-11-05 }}</ref> - [https://www.researchgate.net/publication/354943608_Molecular_evidence_of_autophagy_impairment_as_serum_level_of_ATG13_is_elevated_in_patients_with_myalgic_encephalomyelitis_and_chronic_fatigue_syndrome_two_independent_case-control_studies (Pre-print, Full text)] * 2022, Elevated ATG13 in serum of patients with ME/CFS stimulates oxidative stress response in microglial cells via activation of receptor for advanced glycation end products (RAGE)<ref name="Roy2022">{{Cite journal | title = Elevated ATG13 in serum of patients with ME/CFS stimulates oxidative stress response in microglial cells via activation of receptor for advanced glycation end products (RAGE) | date = 2022-05-01 | url = https://www.sciencedirect.com/science/article/pii/S1044743122000379 | journal = Molecular and Cellular Neuroscience | volume = 120 | issue = | page = 103731 | last = Gottschalk | first = Carl G | author-link = Gunnar Gottschalk | last2 = Peterson | first2 = Daniel | author-link2 = Daniel Peterson | last3 = Knox | first3 = Konstance | author-link3 = | last4 = Maynard | first4 = Marco | author-link4 = | last5 = Whelan | first5 = Ryan J. | author-link5 = | last6 = Roy | first6 = Avik | author-link6 = Roy Avik |doi=10.1016/j.mcn.2022.103731|pmc=|pmid= |issn=1044-7431|quote=|via=}}</ref> - [https://www.sciencedirect.com/science/article/abs/pii/S1044743122000379 (Abstract)] ==See also == *[[Genetics of chronic fatigue syndrome]] *[[Mouse model of chronic fatigue syndrome]] ==Learn more == *[https://www.genecards.org/cgi-bin/carddisp.pl?gene=ATG13 ATG13 Gene] - Gene cards *May 2022, [https://www.simmaronresearch.com/blog/seeing-mecfs-creating-the-first-mouse-models-for-the-disease Seeing ME/CFS: Creating the First Mouse Models for the Disease] - Simmaron Research *Sep 2022, [https://www.simmaronresearch.com/blog/cleaning-crisis-is-defective-mitochondrial-cleanup-in-mecfs-may-be-impairing-energy-production Cleaning Crisis? Is Defective Mitochondrial Cleanup Impairing Energy Production in ME/CFS?] - Simmaron Research ==References == {{Reflist}} [[Category:Genes]] [[Category:Proteins]]
Summary:
Please make sure your edits are consistent with
MEpedia's guidelines
.
By saving changes, you agree to the
Terms of use
, and you irrevocably agree to release your contribution under the
CC BY-SA 3.0 License
and the
GFDL
. You agree that a hyperlink or URL is sufficient attribution under the Creative Commons license.
Cancel
Editing help
(opens in new window)
Templates used on this page:
Template:Asbox
(
edit
)
Template:Cite journal
(
edit
)
Template:Cite web
(
edit
)
Template:Full stop
(
edit
)
Template:Full stop character
(
edit
)
Template:GetFallback
(
edit
)
Template:Help improve text
(
edit
)
Template:LangSwitch
(
edit
)
Template:Main other
(
edit
)
Template:No fullstop
(
edit
)
Template:No fullstop/first
(
edit
)
Template:Reflist
(
edit
)
Template:Str endswith
(
edit
)
Template:Stub
(
view source
) (semi-protected)
Template:Stub text
(
edit
)
Template:Uselang
(
edit
)
Module:Arguments
(
edit
)
Module:Asbox
(
edit
)
Module:Buffer
(
edit
)
Module:Check for unknown parameters
(
edit
)
Module:Citation/CS1
(
edit
)
Module:Citation/CS1/COinS
(
edit
)
Module:Citation/CS1/Configuration
(
edit
)
Module:Citation/CS1/Date validation
(
edit
)
Module:Citation/CS1/Identifiers
(
edit
)
Module:Citation/CS1/Utilities
(
edit
)
Module:Citation/CS1/Whitelist
(
edit
)
Module:Navbar
(
edit
)
Module:No globals
(
edit
)
Module:String
(
edit
)
This page is a member of 2 hidden categories:
Category:All stub articles
Category:Stub pages last edited in 2023
Navigation
Navigation
Skip to content
Main page
Browse
Become an editor
Random page
Popular pages
Abbreviations
Glossary
About MEpedia
Links for editors
Contents
Guidelines
Recent changes
Pages in need
Search
Help
Wiki tools
Wiki tools
Special pages
Page tools
Page tools
User page tools
More
What links here
Related changes
Page information
Page logs