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{{stub}} '''Antiviral drugs''' are a class of medication used specifically for treating [[Virus|viral infections]], rather than [[Bacteria|bacterial]], fungal or other infections. Most antivirals are used for a specific type of virus, while a broad-spectrum antiviral is effective against a wider range of viruses. Although there are a number of broad-spectrum [[Antibiotic|antibiotics]], there are very few broad-spectrum antiviral drugs, and the few in existence are generally only effective against a specific family of viruses.{{citation needed | date = 2022}} [[Tenofovir]] and [[lamivudine]] are antiviral drugs which are designed for HIV, but may be effective against other retroviruses. In addition, it has shown in vitro efficacy against the Epstein Barr virus (EBV) [[Valacyclovir|and it may work against other herpes viruses as well.]] Tenofovir Alafenide (TAF) is the type of tenofovir which shows the greatest efficacy against EBV. [[Valacyclovir]] is often used for [[Herpes simplex virus|Herpes Simplex Virus]] (HSV) I and II, as well as for [[Varicella zoster virus|Varicella Zoster Virus]] (VZV), another [[herpesvirus]]es. [[Valganciclovir]] is used for a broader spectrum of herpesviruses, including HSV I and II, VZV, [[cytomegalovirus]] (CMV), [[Epstein-Barr virus]] (EBV), and is somewhat effective against Human Herpesvirus 6 (HHV6). [[Ribavirin]] is an antiviral drug effective against RNA viruses, although it is rarely used due to its toxic side-effects. Other antiviral drugs that can be effective against RNA viruses include Ivermectin, Paxlovid, Maraviroc and other antivirals that are typically used to treat covid-19, HIV and other RNA viruses. ==Evidence== ==Importance to ME/CFS== ==Studies== *2006, Use of [[valganciclovir]] in patients with elevated antibody titers against [[Human herpesvirus 6|Human Herpesvirus-6]] (HHV-6) and [[Epstein-Barr virus|Epstein-Barr Virus]] (EBV) who were experiencing [[central nervous system]] dysfunction including long-standing [[fatigue]].<ref>{{Cite journal | last = Kogelnik | first = AM | author-link = Andreas Kogelnik | last2 = Loomis | first2 = K | last3 = Hoegh-Petersen | first3 = M | last4 = Rosso | first4 = F | last5 = Hischier | first5 = C | last6 = Montoya | first6 = JG | author-link6 = Jose Montoya | date = | title = Use of valganciclovir in patients with elevated antibody titers against Human Herpesvirus-6 (HHV-6) and Epstein-Barr Virus (EBV) who were experiencing central nervous system dysfunction including long-standing fatigue | url =https://www.ncbi.nlm.nih.gov/pubmed/17276366 | journal = Journal of Clinical Virology | volume = 37| pages=Suppl 1:S33-8|doi=10.1016/S1386-6532(06)70009-9|pmid=17276366|via=}}</ref> [https://www.ncbi.nlm.nih.gov/pubmed/17276366 (Abstract)] * 2012, Response to valganciclovir in chronic fatigue syndrome patients with human herpesvirus 6 and Epstein-Barr virus IgG antibody titers<ref name="Watt, 2012">{{Cite journal | last1 = Watt | first1 = T | author-link1 = | last2 = Oberfoell | first2 = S | author-link2 = | last3 = Balise | first3 = R | author-link3 = | last4 = Lunn | first4 = MR | author-link4 = | last5 = Kar | first5 = AK | author-link5 = | last6 = Merrihew | first6 = LE | author-link6 = | last7 = Bhangoo | first7 = MS | author-link8 =Jose Montoya | last8 =Montoya | first8 = JG | title = Response to valganciclovir in chronic fatigue syndrome patients with human herpesvirus 6 and Epstein-Barr virus IgG antibody titers | journal = Journal of Medical Virology | volume = 84 | issue = 12 | page = 1967-1974 | date = 2012 | pmid = 23080504 | doi = 10.1002/jmv.23411 | url = https://doi.org/10.1002%2Fjmv.23411 }}</ref> ([https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.23411 Abstract]) * 2017, A [[famciclovir]] + [[celecoxib]] combination treatment is safe and efficacious in the treatment of fibromyalgia.<ref>{{Cite journal | last = Pridgen | first = William L | author-link = William Pridgen | last2 = Duffy | first2 = Carol | author-link2 = Carol Duffy | last3 = Gendreau | first3 = Judy F | author-link3 = Judy Gendreau | last4 = Gendreau | first4 = R Michael | author-link4 = Michael Gendreau | author-link5 = | date = 2017-02-22 | title = A famciclovir + celecoxib combination treatment is safe and efficacious in the treatment of fibromyalgia | url = https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328426/ | journal = Journal of Pain Research | volume = 10 | issue = | pages = 451β460|doi=10.2147/JPR.S127288|issn=1178-7090|pmc=5328426|pmid=28260944|quote=|via=}}</ref> ([https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328426/ Full text]) * 2018, [[Migraine]] Headache Treated with [[Famciclovir]] and [[Celecoxib]]: A Case Report.<ref>{{Cite journal | last = NaPier | first = Bradford Lee | author-link = | last2 = Morimoto | first2 = Maki | author-link2 = | last3 = NaPier | first3 = Erin | date = 2017-11-29 | title = Migraine Headache Treated with Famciclovir and Celecoxib: A Case Report | url = https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737915/ | journal = The Permanente Journal | volume = 22 | issue = | pages=|doi=10.7812/TPP/17-020|issn=1552-5767|pmc=5737915|pmid=29236660|quote=|via=}}</ref> ([https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737915/ Full text]) ==See also== * [[Jose Montoya]] * [[Vagus nerve infection hypothesis]] * [[Viral onset hypothesis]] ==Learn more == ==References== {{reflist}} [[Category:Potential treatments]] [[Category:Antivirals]]
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