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Alpha-lipoic acid
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==== Multiple Sclerosis ==== A small pilot study designed to evaluate the safety of lipoic acid in 30 people with relapsing or progressive multiple sclerosis found that treatment with 1,200 to 2,400 mg/day of oral lipoic acid for 2 weeks was safe. Those with the higher serum concentrations of lipoic acid had the lowest serum concentrations of MMP-9 — a marker of inflammation.<ref>{{Cite journal | last = Yadav | first = V. | last2 = Marracci | first2 = G. | last3 = Lovera | first3 = J. | last4 = Woodward | first4 = W. | last5 = Bogardus | first5 = K. | last6 = Marquardt | first6 = W. | last7 = Shinto | first7 = L. | last8 = Morris | first8 = C. | last9 = Bourdette | first9 = D. | date = Apr 2005 | title = Lipoic acid in multiple sclerosis: a pilot study | url = https://www.ncbi.nlm.nih.gov/pubmed/15794388 | journal = Multiple Sclerosis (Houndmills, Basingstoke, England) | volume = 11 | issue = 2 | pages = 159–165|doi=10.1191/1352458505ms1143oa|issn=1352-4585|pmid=15794388|pmc=|quote=|access-date=|via=}}</ref> A 2-year trial of 1,200 mg/day LA in secondary progressive MS demonstrated a significant reduction of whole-brain atrophy and trend toward improvement in walking speed.<ref name=":1" />
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