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Acetylcholine
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=== Acetylcholinesterase inhibitors === [[Acetylcholinesterase]] is an enzyme that breaks down acetylcholine. Acetylcholinesterase inhibitors block or downregulate the activity of acetylcholinesterase; in turn, because there is less enzyme breaking down acetylcholine, the amount of circulating acetylcholine increases. The following compounds are acetylcholinesterase inhibitors: * [[pyridostigmine]] (Mestinon) - A peripheral AChE inhibitor, pyridostigmine is unable to cross the blood brain barrier due to its chemical structure. <ref>{{Cite journal | last = Anderson | first = Tim | last2 = Pope | first2 = Carey N. | date = 2017 | title = Pyridostigmine β | journal = =J. Med. Chem. | url = https://linkinghub.elsevier.com/retrieve/pii/B978012801238397627X|language=en| publisher = Elsevier| pages=B978012801238397627X|doi=10.1016/b978-0-12-801238-3.97627-x|isbn=978-0-12-801238-3}}</ref> * [[huperzine A]] (crosses blood-brain barrier){{Citation needed}} * galantamine - A central/peripheral AChE inhibitor. While prescription only in some countries, galantamine is available over the counter in the United States. * blueberries<ref>{{Cite journal | last = Papandreou | first = Magdalini A. | last2 = Dimakopoulou | first2 = Andriana | last3 = Linardaki | first3 = Zacharoula I. | last4 = Cordopatis | first4 = Paul | last5 = Klimis-Zacas | first5 = Dorothy | last6 = Margarity | first6 = Marigoula | last7 = Lamari | first7 = Fotini N. | date = 2009-03-17 | title = Effect of a polyphenol-rich wild blueberry extract on cognitive performance of mice, brain antioxidant markers and acetylcholinesterase activity | url = https://www.ncbi.nlm.nih.gov/pubmed/19056430 | journal = Behavioural Brain Research | volume = 198 | issue = 2 | pages = 352β358|doi=10.1016/j.bbr.2008.11.013|issn=1872-7549|pmid=19056430}}</ref>
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