Anonymous
Not logged in
Talk
Contributions
Create account
Log in
Search
Editing
A Regime for Antiretroviral Treatment of Myalgic Encephalomyelitis
(section)
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
Namespaces
Page
Discussion
More
More
Page actions
Read
Edit
Edit source
History
Warning:
You are not logged in. Your IP address will be publicly visible if you make any edits. If you
log in
or
create an account
, your edits will be attributed to your username, along with other benefits.
Anti-spam check. Do
not
fill this in!
===Mitochondria=== Most often mitochondrial function is being doctored with all possible means in ME patients - not seldom with the result that the patient is subsequently even worse off. But what if strengthening of the [[Mitochondrion|mitochondria]] leads to cells infected with a possible [[retrovirus]] also being strengthened and thus able to multiply even faster? Therefore, it is in my opinion important to first of all gain control over the possible [[retrovirus]] and all other, mostly occult viruses and bacterial infections. By the way, mitochondrial function, which is reduced by disease, repairs all by itself through [[ART]] - at least this is our experience. That is why strengthening the mitochondrial function while taking synthetic [[ARV]] is primarily about buffering potentially harmful effects of the drugs. Time-displaced to [[Viread]]/[[Vemlidy]] intake, N- acetylcysteine ([[NAC]], caution in case of [[histamine]] intolerance!), [[glutathione]] or [[Niacinamide]] (vitamin B3 flush-free) is suitable for this purpose. Actually, it has been proven in vitro that [[NAC]] and [[glutathione]] also suppress the replication of [[HIV]]- 1 and are therefore antiretrovirally active in addition to their mitochdria-strengthening properties. Especially in [[HIV]] patients with advanced immunodeficiency, a short-term, high-dose combination treatment with NAC and vitamin C seems to be of therapeutic value. Glutathione deficiency is also common in [[HIV]]-infected individuals and therefore administration of NAC seems to be a useful supplementary therapy, not only to increase protection against oxidative stress and improve immune system functionality, but also to promote the detoxification of drugs. Treatment with [[NAC]] could therefore also be useful for other diseases in which [[glutathione]] deficiency or oxidative stress plays a role (such as ME!) - according to the results of a study on [[HIV]]. [[Niacinamide]] (vitamin B3), especially nicotinamide riboside, has proven to be a promising treatment strategy for mitochondrial myopathy in animal models. It has beneficial effects on energy metabolism and neuroprotection. But what could be even more crucial: Niacinamide seems to be effective against multi-resistant germs, which even healthy people, but especially ME patients, are often abundantly populated with. A population which a healthy person can usually cope with well could possibly have a devastating effect on weakened ME patients combined with viral loads. With niacinamide flush-free 500mg daily, a dose still below the tolerable upper intake level set by the European Food Safety Authority, a low-cost option for controlling these hospital germs is available.
Summary:
Please make sure your edits are consistent with
MEpedia's guidelines
.
By saving changes, you agree to the
Terms of use
, and you irrevocably agree to release your contribution under the
CC BY-SA 3.0 License
and the
GFDL
. You agree that a hyperlink or URL is sufficient attribution under the Creative Commons license.
Cancel
Editing help
(opens in new window)
Navigation
Navigation
Skip to content
Main page
Browse
Become an editor
Random page
Popular pages
Abbreviations
Glossary
About MEpedia
Links for editors
Contents
Guidelines
Recent changes
Pages in need
Search
Help
Wiki tools
Wiki tools
Special pages
Page tools
Page tools
User page tools
More
What links here
Related changes
Page information
Page logs