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[[File:Dr. Martin Lerner.png|thumb|Source: treatmentcenterforcfs.com]]
[[File:Dr. Martin Lerner.png|thumb|Source: treatmentcenterforcfs.com]]
Dr. '''A. Martin Lerner''' (also known as '''Martin Lerner''') was a much beloved and respected ME/CFS specialist who died in October 2015, at the age of 86.<ref>http://www.irakaufman.com/mobile/detail.php?id=5990</ref>
Dr. '''A. Martin Lerner''', aka '''Martin Lerner,''' (d. 2015) was a much beloved and respected [[ME/CFS|Myalgic Encephalomyelitis/Chronic Fatigue Syndrome]] specialist who died in October 2015, at the age of 86.<ref>http://www.irakaufman.com/mobile/detail.php?id=5990</ref>


He was one of the experts on the "Committee on the Diagnostic Criteria for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome" that was convened for the 2015 [[Institute of Medicine report]],<ref>http://www.ncbi.nlm.nih.gov/books/NBK284904/</ref> as well as, one of the authors of the 2003 [[Canadian Consensus Criteria]] for Myalgic Encephalomyelitis, published as [http://phoenixrising.me/wp-content/uploads/Canadian-definition.pdf ''Myalgic Encephalomyelitis/Chronic Fatigue Syndrome:Clinical Working Case Definition,Diagnostic and Treatment Protocols'']<ref>http://phoenixrising.me/wp-content/uploads/Canadian-definition.pdf</ref>
He was one of the experts on the [[Institute of Medicine report|"Committee on the Diagnostic Criteria for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome"]] that was convened for the 2015 [[Institute of Medicine report]],<ref>{{Cite book | title = Biographical Sketches of Committee Members, Consultants, and Staff|language=en | url =https://www.ncbi.nlm.nih.gov/books/NBK284904/ | date = 2015-02-10| publisher = National Academies Press (US) | last = Syndrome | first = Committee on the Diagnostic Criteria for Myalgic Encephalomyelitis/Chronic Fatigue | last2 = Populations | first2 = Board on the Health of Select | last3 = Medicine | first3 = Institute of}}</ref> as well as, one of the authors of the 2003 [[Canadian Consensus Criteria]] for Myalgic Encephalomyelitis, published as [http://phoenixrising.me/wp-content/uploads/Canadian-definition.pdf ''Myalgic Encephalomyelitis/Chronic Fatigue Syndrome:Clinical Working Case Definition,Diagnostic and Treatment Protocols'']<ref>http://phoenixrising.me/wp-content/uploads/Canadian-definition.pdf</ref>


He was a strong advocate of using antivirals because he hypothesized CFS is caused by 3 [[herpesvirus]]es: [[Epstein-Barr virus]], [[cytomegalovirus]] and/or [[Human herpesvirus 6]]. "These three viruses establish “latent” infection in B-lymphocytes, monocyte-macrophage precursors, or T-lymphocytes respectively. Virus reactivation, and both abortive and complete virus multiplication occur. Therefore CFS patients have been described with continuing primary or reactivated infections.<ref>"http://treatmentcenterforcfs.com/personal_statement/index.html</ref>
He was a strong advocate of using antivirals because he hypothesized CFS is caused by 3 [[herpesvirus]]es: [[Epstein-Barr virus]], [[cytomegalovirus]] and/or [[Human herpesvirus 6]]. "These three viruses establish “latent” infection in B-lymphocytes, monocyte-macrophage precursors, or T-lymphocytes respectively. Virus reactivation, and both abortive and complete virus multiplication occur. Therefore CFS patients have been described with continuing primary or reactivated infections.<ref>"http://treatmentcenterforcfs.com/personal_statement/index.html</ref>


==Notable Studies==
==Notable studies in ME/CFS==
*2012, [http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0047891 Antibody to Epstein-Barr Virus Deoxyuridine Triphosphate Nucleotidohydrolase and Deoxyribonucleotide Polymerase in a Chronic Fatigue Syndrome Subset (FULL TEXT)]<blockquote> Abstract - "Background: A defined diagnostic panel differentiated patients who had been diagnosed with chronic fatigue syndrome (CFS), based upon Fukuda/Carruthers criteria. This diagnostic panel identified an Epstein-Barr virus (EBV) subset of patients (6), excluding for the first time other similar “clinical” conditions such as cytomegalovirus (CMV), human herpesvirus 6 (HHV6), babesiosis, ehrlichiosis, borreliosis, Mycoplasma pneumoniae, Chlamydia pneumoniae, and adult rheumatic fever, which may be mistakenly called CFS. CFS patients were treated with valacyclovir (14.3 mg/kg q6h) for ≥12 months. Each patient improved, based upon the Functional Activity Appraisal: Energy Index Score Healthcare Worker Assessment (EIPS), which is a validated (FSS-9), item scale with high degree of internal consistency measured by Cronbach's alpha. Methods: Antibody to EBV viral capsid antigen (VCA) IgM, EBV Diffuse Early Antigen EA(D), and neutralizing antibodies against EBV-encoded DNA polymerase and EBV-encoded dUTPase were assayed serially approximately every three months for 13–16 months from sera obtained from patients with CFS (6) and from sera obtained from twenty patients who had no history of CFS. Results: Antibodies to EBV EA(D) and neutralizing antibodies against the encoded-proteins EBV DNA polymerase and deoxyuridine triphosphate nucleotidohydrolase (dUTPase) were present in the EBV subset CFS patients. Of the sera samples obtained from patients with CFS 93.9% were positive for EA(D), while 31.6% of the control patients were positive for EBV EA(D). Serum samples were positive for neutralizing antibodies against the EBV-encoded dUTPase (23/52; 44.2%) and DNA polymerase (41/52; 78.8%) in EBV subset CFS patients, but negative in sera of controls. Conclusions: There is prolonged elevated antibody level against the encoded proteins EBV dUTPase and EBV DNA polymerase in a subset of CFS patients, suggesting that this antibody panel could be used to identify these patients, if these preliminary findings are corroborated by studies with a larger number of EBV subset CFS patients."<ref name="Lerner, 2012"/></blockquote>
*2003, [[Myalgic encephalomyelitis|Myalgic Encephalomyelitis]]/[[Chronic fatigue syndrome|Chronic Fatigue Syndrome]]: Clinical Working Case Definition, Diagnostic and Treatment Protocols<ref name="Carruthers, 2003" /> - [http://phoenixrising.me/wp-content/uploads/Canadian-definition.pdf (Full Text)]
*2003, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Clinical Working Case Definition, Diagnostic and Treatment Protocols<blockquote>"Abstract - Recent years have brought growing recognition of the need for clinical criteria for myalgic encephalomyelitis (ME), which is also called chronic fatigue syndrome (CFS). An Expert Subcommittee of Health Canada established the Terms of Reference, and selected an Expert Medical Consensus Panel representing treating physicians, teaching faculty and researchers. A Consensus Workshop was held on March 30 to April 1, 2001 to culminate the review process and establish consensus for a clinical working case definition, diagnostic protocols and treatment protocols. We present a systematic clinical working case definition that encourages a diagnosis based on characteristic patterns of symptom clusters, which reflect specific areas of pathogenesis. Diagnostic and treatment protocols, and a short overview of research are given to facilitate a comprehensive and integrated approach to this illness. Throughout this paper, “myalgic encephalomyelitis” and “chronic fatigue syndrome” are used interchangeably and this illness is referred to as “ME/CFS.”<ref name="Carruthers, 2003"/></blockquote>
*2012, Antibody to Epstein-Barr Virus Deoxyuridine Triphosphate Nucleotidohydrolase and Deoxyribonucleotide Polymerase in a Chronic Fatigue Syndrome Subset<ref name="Lerner, 2012" /> - [http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0047891 (Full Text)]


==Talks & interviews==
==Talks and interviews==


===Talks on Lerner's webpage===
===Talks on Lerner's webpage===


*[http://treatmentcenterforcfs.com/video/2007.html August 22, 2007] – Dr. A Martin Lerner presenting Medical Grand Rounds at William Beaumont Hospital in Royal Oak, MI on the Topic of Chronic Fatigue Syndrome.
*August 22, 2007 – Dr. A Martin Lerner presenting Medical Grand Rounds at William Beaumont Hospital in Royal Oak, MI on the Topic of Chronic Fatigue Syndrome. - [http://treatmentcenterforcfs.com/video/2007.html (Video)]
*[http://treatmentcenterforcfs.com/video/2008.html May 23, 2008] – Dr. A Martin Lerner’s presentation on The Sub-grouping & Treatment for ME/CFS, at the 3rd annual Invest in ME International ME/CFS Conference in London, England.
*May 23, 2008 – Dr. A Martin Lerner’s presentation on The Sub-grouping & Treatment for ME/CFS, at the 3rd annual Invest in ME International ME/CFS Conference in London, England. - [http://treatmentcenterforcfs.com/video/2008.html (Video)]
*[http://treatmentcenterforcfs.com/video/2010.html October 12, 2010] – Dr. A Martin Lerner’s presentation on Successful Antiviral Treatment of CFS and Its Science at the CFSAC biannual meeting hosted by the Department of Health and Human Services in Washington, DC.
*October 12, 2010 – Dr. A Martin Lerner’s presentation on Successful Antiviral Treatment of CFS and Its Science at the CFSAC biannual meeting hosted by the Department of Health and Human Services in Washington, DC. - [http://treatmentcenterforcfs.com/video/2010.html (Video)]
*[http://treatmentcenterforcfs.com/video/2011-prt1.html August 20, 2011 Part 1] – Dr. A Martin Lerner presenting at William Beaumont Hospital in Royal Oak, MI to infectious disease physicians in Michigan "A Primer on ME/CFS -Background, Virology, Immunology, Pathologic Physiology, Diagnosis and Treatment." [http://treatmentcenterforcfs.com/video/documents/Dr.AMLerner-PrimeronMECFS.pdf PDF Download of presentation slides] [http://treatmentcenterforcfs.com/video/documents/MECFSTreatmentResourceGuideforPractitioners.pdf PDF Download of ME/CFS Treatment Resource Guide for Practitioners]
*August 20, 2011, Part 1 – Dr. A Martin Lerner presenting at William Beaumont Hospital in Royal Oak, MI to infectious disease physicians in Michigan "A Primer on ME/CFS -Background, Virology, Immunology, Pathologic Physiology, Diagnosis and Treatment." - [http://treatmentcenterforcfs.com/video/2011-prt1.html (Video)]; [http://treatmentcenterforcfs.com/video/documents/Dr.AMLerner-PrimeronMECFS.pdf PDF Download of presentation slides]; [http://treatmentcenterforcfs.com/video/documents/MECFSTreatmentResourceGuideforPractitioners.pdf PDF Download of ME/CFS Treatment Resource Guide for Practitioners]
*[http://treatmentcenterforcfs.com/video/2011-prt2.html August 20, 2011 Part 2] – Dr. A Martin Lerner presenting at William Beaumont Hospital in Royal Oak, MI to infectious disease physicians in Michigan "A Primer on ME/CFS -Background, Virology, Immunology, Pathologic Physiology, Diagnosis and Treatment." [http://treatmentcenterforcfs.com/video/documents/Dr.AMLerner-PrimeronMECFS.pdf PDF Download of presentation slides] [http://treatmentcenterforcfs.com/video/documents/MECFSTreatmentResourceGuideforPractitioners.pdf PDF Download of ME/CFS Treatment Resource Guide for Practitioners]
*August 20, 2011, Part 2 – Dr. A Martin Lerner presenting at William Beaumont Hospital in Royal Oak, MI to infectious disease physicians in Michigan "A Primer on ME/CFS -Background, Virology, Immunology, Pathologic Physiology, Diagnosis and Treatment."- [http://treatmentcenterforcfs.com/video/2011-prt2.html (Video)]; [http://treatmentcenterforcfs.com/video/documents/Dr.AMLerner-PrimeronMECFS.pdf PDF Download of presentation slides]; [http://treatmentcenterforcfs.com/video/documents/MECFSTreatmentResourceGuideforPractitioners.pdf PDF Download of ME/CFS Treatment Resource Guide for Practitioners]


===Invest in ME International ME Conference===
===Invest in ME International ME Conference===
*2008, Speaker at the 3rd Invest in ME International ME Conference on ''Diagnosis and Treatment of ME/CFS - Longitudinal Observations of Cardiac and Antiviral studies''<ref>http://www.investinme.eu/IIMEC3.shtml#agenda</ref> [http://www.investinme.eu/IIMEC3.shtml#dvd DVD available]
*2008, Speaker at the 3rd Invest in ME International ME Conference on ''Diagnosis and Treatment of ME/CFS - Longitudinal Observations of Cardiac and Antiviral studies''<ref>http://www.investinme.org/IIMEC3.shtml#agenda</ref> - [https://www.youtube.com/watch?v=S0qn9zK0znc (Video)]


==Online presence==
==Online presence==
[http://treatmentcenterforcfs.com/index.html Treatment Center for CFS]
* [http://web.archive.org/web/20190327093352/http://www.treatmentcenterforcfs.com/ Treatment Center for CFS]
* [https://mecfsviralresearch.altervista.org Dr Lerner's Published Studies] Also [http://web.archive.org/web/20191101170704/http://www.treatmentcenterforcfs.com/cfs_publications/index.html here].


==Learn more==
==Learn more==
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==See also==
==See also==
*[[Energy Index Point Score]]
*[[Energy Index Point Score]]
*[[Abortive infection theory of ME/CFS]] (Dr Lerner's theory that abortive herpesviruses cause ME/CFS)


==References==
==References==
<references>
<references>
<ref name="Carruthers, 2003">
<ref name="Carruthers, 2003">{{Citation | last1 = Carruthers | first1 = Bruce M. | author-link1 = Bruce Carruthers | last2 = Jain | first2 = Anil Kumar | authorlink2 = Anil Kumar Jain | last3 = De Meirleir | first3 = Kenny L. | author-link3 = Kenny De Meirleir | last4 = Peterson | first4 = Daniel L. | author-link4 = Daniel Peterson | last5 = Klimas | first5 = Nancy G. | author-link5 = Nancy Klimas | last6 = Lerner | first6 = A. Martin | author-link6 = Martin Lerner | last7 = Bested | first7 = Alison C. | author-link8 = Alison Bested | last8 = Flor-Henry | first8 = Pierre | author-link8 = Pierre Flor-Henry | last9 =Joshi | first9 = Pradip | author-link9 = Pradip Joshi | last10= Powles | first10 = AC Peter | author-link10 = A C Peter Powles | last11= Sherkey | first11 = Jeffrey A. | author-link11 = Jeffrey Sherkey | last12= van de Sande | first12 = Marjorie I. | author-link12 = Marjorie van de Sande | title = Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Clinical Working Case Definition, Diagnostic and Treatment Protocols | journal = Journal of Chronic Fatigue Syndrome | volume = 11 | issue = 2 | pages = 7-115 | date = 2003 | pmid= | doi= 10.1300/J092v11n01_02 | url = http://phoenixrising.me/wp-content/uploads/Canadian-definition.pdf }}</ref>
{{Citation
<ref name="Lerner, 2012">{{Citation | last1 = Lerner | first1 = AM | author-link1 = A Martin Lerner | last2 = Ariza | first2 = ME | authorlink2 = | last3 =Williams | first3 = M | author-link3 = | last4 = Jason | first4 = L | author-link4 = Leonard Jason | last5 = Beqaj | first5 = S | author-link5 = | last6 = Fitzgerald | first6 = JT | author-link6 = | last7 = Lemeshow | first7 = S | author-link7 = | last8 = Glaser | first8 = R | author-link8 = Ronald Glaser | title = Antibody to Epstein-Barr Virus Deoxyuridine Triphosphate Nucleotidohydrolase and Deoxyribonucleotide Polymerase in a Chronic Fatigue Syndrome Subset | journal = PLoS ONE | volume = 7 | issue = 11 | page = e47891 | date = 2012 | pmid= | doi= 10.1371/journal.pone.0047891 }}</ref>
| last1   = Carruthers       | first1 = Bruce M.           | authorlink1 = Bruce Carruthers  
| last2   = Jain             | first2 = Anil Kumar         | authorlink2 = Anil Kumar Jain
| last3   = De Meirleir       | first3 = Kenny L.           | authorlink3 = Kenny De Meirleir
| last4   = Peterson         | first4 = Daniel L.         | authorlink4 = Daniel Peterson
| last5   = Klimas           | first5 = Nancy G.           | authorlink5 = Nancy Klimas
| last6   = Lerner           | first6 = A. Martin         | authorlink6 = Martin Lerner
| last7   = Bested           | first7 = Alison C.         | authorlink7 = Alison Bested
| last8   = Flor-Henry       | first8 = Pierre             | authorlink8 = Pierre Flor-Henry  
| last9   = Joshi             | first9 = Pradip             | authorlink9 = Pradip Joshi
| last10   = Powles           | first10 = A C Peter         | authorlink10 = A C Peter Powles
| last11   = Sherkey         | first11 = Jeffrey A.       | authorlink11 = Jeffrey Sherkey
| last12   = van de Sande     | first12 = Marjorie I.       | authorlink12 = Marjorie van de Sande
| title   = Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Clinical Working Case Definition, Diagnostic and Treatment Protocols
| journal = Journal of Chronic Fatigue Syndrome   | volume = 11   | issue = 2   | page = 7-115
| date   = 2003
| pmid   =  
| doi     = 10.1300/J092v11n01_02
}}</ref>
<ref name="Lerner, 2012">
{{Citation
| last1   = Lerner                 | first1 = AM                   | authorlink1 = A Martin Lerner
| last2   = Ariza                 | first2 = ME                   | authorlink2 =  
| last3   = Williams                 | first3 = M                   | authorlink3 =  
| last4   = Jason                 | first4 = L                   | authorlink4 = Leonard Jason
| last5   = Beqaj                 | first5 = S                   | authorlink5 =  
| last6   = Fitzgerald                 | first6 = JT                   | authorlink6 =  
| last7   = Lemeshow                 | first7 = S                   | authorlink7 =  
| last8   = Glaser                 | first8 = R                   | authorlink8 = Ronald Glaser
| title   = Antibody to Epstein-Barr Virus Deoxyuridine Triphosphate Nucleotidohydrolase and Deoxyribonucleotide Polymerase in a Chronic Fatigue Syndrome Subset
| journal = PLoS ONE   | volume = 7   | issue = 11   | page = e47891
| date   = 2012
| pmid   =  
| doi     = 10.1371/journal.pone.0047891
}}
</ref>
</references>
</references>
 
[[Category:American clinicians]]  
[[Category:Clinicians]] [[Category:American clinicians]] [[Category:Researchers]] [[Category:USA researchers]][[Category:Michigan clinicians]]
[[Category:US researchers]]
[[Category:Michigan clinicians]]
[[Category:Institute of Medicine report committee members]]

Latest revision as of 22:33, August 30, 2023

Source: treatmentcenterforcfs.com

Dr. A. Martin Lerner, aka Martin Lerner, (d. 2015) was a much beloved and respected Myalgic Encephalomyelitis/Chronic Fatigue Syndrome specialist who died in October 2015, at the age of 86.[1]

He was one of the experts on the "Committee on the Diagnostic Criteria for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome" that was convened for the 2015 Institute of Medicine report,[2] as well as, one of the authors of the 2003 Canadian Consensus Criteria for Myalgic Encephalomyelitis, published as Myalgic Encephalomyelitis/Chronic Fatigue Syndrome:Clinical Working Case Definition,Diagnostic and Treatment Protocols[3]

He was a strong advocate of using antivirals because he hypothesized CFS is caused by 3 herpesviruses: Epstein-Barr virus, cytomegalovirus and/or Human herpesvirus 6. "These three viruses establish “latent” infection in B-lymphocytes, monocyte-macrophage precursors, or T-lymphocytes respectively. Virus reactivation, and both abortive and complete virus multiplication occur. Therefore CFS patients have been described with continuing primary or reactivated infections.[4]

Notable studies in ME/CFS[edit | edit source]

Talks and interviews[edit | edit source]

Talks on Lerner's webpage[edit | edit source]

  • August 22, 2007 – Dr. A Martin Lerner presenting Medical Grand Rounds at William Beaumont Hospital in Royal Oak, MI on the Topic of Chronic Fatigue Syndrome. - (Video)
  • May 23, 2008 – Dr. A Martin Lerner’s presentation on The Sub-grouping & Treatment for ME/CFS, at the 3rd annual Invest in ME International ME/CFS Conference in London, England. - (Video)
  • October 12, 2010 – Dr. A Martin Lerner’s presentation on Successful Antiviral Treatment of CFS and Its Science at the CFSAC biannual meeting hosted by the Department of Health and Human Services in Washington, DC. - (Video)
  • August 20, 2011, Part 1 – Dr. A Martin Lerner presenting at William Beaumont Hospital in Royal Oak, MI to infectious disease physicians in Michigan "A Primer on ME/CFS -Background, Virology, Immunology, Pathologic Physiology, Diagnosis and Treatment." - (Video); PDF Download of presentation slides; PDF Download of ME/CFS Treatment Resource Guide for Practitioners
  • August 20, 2011, Part 2 – Dr. A Martin Lerner presenting at William Beaumont Hospital in Royal Oak, MI to infectious disease physicians in Michigan "A Primer on ME/CFS -Background, Virology, Immunology, Pathologic Physiology, Diagnosis and Treatment."- (Video); PDF Download of presentation slides; PDF Download of ME/CFS Treatment Resource Guide for Practitioners

Invest in ME International ME Conference[edit | edit source]

  • 2008, Speaker at the 3rd Invest in ME International ME Conference on Diagnosis and Treatment of ME/CFS - Longitudinal Observations of Cardiac and Antiviral studies[7] - (Video)

Online presence[edit | edit source]

Learn more[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

  1. ↑ http://www.irakaufman.com/mobile/detail.php?id=5990
  2. ↑ Syndrome, Committee on the Diagnostic Criteria for Myalgic Encephalomyelitis/Chronic Fatigue; Populations, Board on the Health of Select; Medicine, Institute of (February 10, 2015). Biographical Sketches of Committee Members, Consultants, and Staff. National Academies Press (US).
  3. ↑ http://phoenixrising.me/wp-content/uploads/Canadian-definition.pdf
  4. ↑ "http://treatmentcenterforcfs.com/personal_statement/index.html
  5. ↑ Carruthers, Bruce M.; Jain, Anil Kumar; De Meirleir, Kenny L.; Peterson, Daniel L.; Klimas, Nancy G.; Lerner, A. Martin; Bested, Alison C.; Flor-Henry, Pierre; Joshi, Pradip; Powles, AC Peter; Sherkey, Jeffrey A.; van de Sande, Marjorie I. (2003), "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Clinical Working Case Definition, Diagnostic and Treatment Protocols" (PDF), Journal of Chronic Fatigue Syndrome, 11 (2): 7–115, doi:10.1300/J092v11n01_02
  6. ↑ Lerner, AM; Ariza, ME; Williams, M; Jason, L; Beqaj, S; Fitzgerald, JT; Lemeshow, S; Glaser, R (2012), "Antibody to Epstein-Barr Virus Deoxyuridine Triphosphate Nucleotidohydrolase and Deoxyribonucleotide Polymerase in a Chronic Fatigue Syndrome Subset", PLoS ONE, 7 (11): e47891, doi:10.1371/journal.pone.0047891
  7. ↑ http://www.investinme.org/IIMEC3.shtml#agenda

myalgic encephalomyelitis (M.E.) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

antibodies Antibody/immunoglobulin refers to any of a large number of specific proteins produced by B cells that act against an antigen in an immune response.

Chronic Fatigue Syndrome Advisory Committee (CFSAC) - (sometimes pronounced SIF-SACK) A US government advisory council that met twice per year, covering current topics related to Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. Meetings usually lasted for two days and the results were presented to the Secretary of Health and Human Services (HHS). After 15 years, on September 5, 2018, CFSAC's charter was not renewed by the Department of HHS, effectively dissolving the committee without notice or warning.

chronic fatigue (CF) - Persistent and abnormal fatigue is a symptom, not an illness. It may be caused by depression, multiple sclerosis, fibromyalgia, chronic fatigue syndrome or many other illnesses. The term "chronic fatigue" should never be confused with the disease chronic fatigue syndrome.

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