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Øystein Fluge
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==Notable ME/CFS Studies== *2011, Benefit from [[B cell|B-lymphocyte]] depletion using the anti-CD20 antibody [[rituximab]] in [[chronic fatigue syndrome]]. A double-blind and placebo-controlled study<ref name="Fluge, 2011" /> - [http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0026358 (Full text)] *2015, [[B cell|B-lymphocyte]] depletion in [[ME/CFS|myalgic encephalopathy/chronic fatigue syndrome]]. An open-label phase II study with [[rituximab]] maintenance treatment<ref>{{Cite journal | last = Fluge | first = Øystein | author-link = Øystein Fluge | last2 = Risa | first2 = Kristin|author-link2 = | last3 = Lunde | first3 = Sigrid | author-link3 = | last4 = Alme | first4 = Kine | author-link4 = | last5 = Rekeland | first5 = Ingrid Gurvin | authorlink5 = |last6 = Sapkota | first6 = Dipak | authorlink6 = | last7 = Kristoffersen | first7 = Einar Kleboe | last8 = Sørland | first8 = Kari | last9 = Bruland | first9 = Ove | date = 2015-07-01 | editor-last = van der Feltz-Cornelis|editor-first = Christina | title = B-Lymphocyte Depletion in Myalgic Encephalopathy/ Chronic Fatigue Syndrome. An Open-Label Phase II Study with Rituximab Maintenance Treatment|url=http://dx.plos.org/10.1371/journal.pone.0129898|journal=PLOS ONE|language=en|volume=10|issue=7| pages = e0129898|doi=10.1371/journal.pone.0129898|issn=1932-6203|pmc=4488509|pmid=26132314|access-date=|quote=|via=}}</ref> - [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488509/ (Full text)] *2016, Metabolic profiling indicates impaired pyruvate dehydrogenase function in myalgic encephalopathy/chronic fatigue syndrome<ref name="Fluge, 2016" /> - [http://insight.jci.org/articles/view/89376 (Full text)] *2016, Serum BAFF and APRIL Levels, T-Lymphocyte Subsets, and Immunoglobulins after B-Cell Depletion Using the Monoclonal Anti-CD20 Antibody Rituximab in Myalgic Encephalopathy/Chronic Fatigue Syndrome.<ref>{{Cite journal | last =Lunde | first = Sigrid | authorlink = | last2 = Kristoffersen | first2=Einar K.|author-link2 = | last3 = Sapkota | first3 = Dipak | authorlink3 = | last4 = Risa | first4 = Kristin | author-link4 = | last5 = Dahl | first5 = Olav | authorlink5 = |last6 = Bruland | first6 = Ove | authorlink6 = | last7 = Mella | first7 = Olav | authorlink7 = Olav Mella | last8 = Fluge | first8 = Øystein | authorlink8 = Øystein Fluge | date = 2016-08-18 | editor-last = Cordero|editor-first = Mario D. | title=Serum BAFF and APRIL Levels, T-Lymphocyte Subsets, and Immunoglobulins after B-Cell Depletion Using the Monoclonal Anti-CD20 Antibody Rituximab in Myalgic Encephalopathy/Chronic Fatigue Syndrome|url=http://dx.plos.org/10.1371/journal.pone.0161226|journal=PLOS ONE|language=en|volume=11|issue=8| pages = e0161226|doi=10.1371/journal.pone.0161226|issn=1932-6203|pmc=|pmid=|access-date=|quote=|via=}}</ref> - [http://dx.plos.org/10.1371/journal.pone.0161226 (Full text)] *2016, Antibodies to β adrenergic and muscarinic cholinergic receptors in patients with Chronic Fatigue Syndrome. The study abstract states: "The association of autoantibodies with immune markers suggests that they activate B and T cells expressing β adrenergic and M acetylcholine receptors. Dysregulation of acetylcholine and adrenergic signalling could also explain various clinical symptoms of CFS."<ref name="Loebel, 2016" /> *2018, Immunosignature Analysis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)<ref>{{Cite journal | last =Günther | first=Oliver P. | last2 = Gardy | first2 = Jennifer L. | last3 = Stafford | first3=Phillip | author-link3 = Phillip Stafford | last4 = Fluge | first4 = Øystein | author-link4 = Øystein Fluge | last5 = Mella | first5 = Olav | authorlink5 = Olav Mella|last6 = Tang | first6 = Patrick | last7 = Miller | first7 = Ruth R. | last8 = Parker | first8 = Shoshana M. | last9 = Johnston | first9 = Stephen A. | date = 2018-10-08 | title = Immunosignature Analysis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)|url=https://link.springer.com/article/10.1007%2Fs12035-018-1354-8|journal=Molecular Neurobiology|language=en|volume=|pages=|doi=10.1007/s12035-018-1354-8|issn=0893-7648|via=}}</ref> - [https://link.springer.com/article/10.1007/s12035-018-1354-8 (Full text)] *2018, [[Rituximab]] Serum Concentrations and Anti-Rituximab Antibodies During B-Cell Depletion Therapy for Myalgic Encephalopathy/Chronic Fatigue Syndrome<ref>{{Cite journal | last =Schjøtt | first=Jan|author-link = | last2 = Vries | first2=Annick de|author-link2 = | last3 = Mella | first3 = Olav | author-link3 = Olav Mella | last4 = Sørland | first4=Kari | author-link4 = Kari | last5 = Risa | first5 = Kristin | authorlink5 = |last6 = Alme | first6 = Kine | last7 = Fluge | first7 = Øystein | authorlink7 = Øystein Fluge | last8 = Rekeland | first8 = Ingrid G. | date = 2018-11-28 | title = Rituximab Serum Concentrations and Anti-Rituximab Antibodies During B-Cell Depletion Therapy for Myalgic Encephalopathy/Chronic Fatigue Syndrome|url=https://www.clinicaltherapeutics.com/article/S0149-2918(18)30514-9/abstract|journal=Clinical Therapeutics|language=English|volume=0|issue=0|pages=|doi=10.1016/j.clinthera.2018.10.019|issn=1879-114X|pmid=30502905|quote=|via=}}</ref> - [https://www.sciencedirect.com/science/article/abs/pii/S0149291818305149 (Abstract)] *2019, [[B cell|B-Lymphocyte]] Depletion in Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial<ref>{{Cite journal | last = Fluge | first = Øystein | author-link = Øystein Fluge | last2 = Rekeland | first2=Ingrid G. | last3 = Lien | first3=Katarina | last4 = Thürmer | first4=Hanne | last5 = Borchgrevink | first5 = Pette C. | last6 = Schäfer | first6 = Christoph | last7 = Sørland | first7 = Kari | last8 = Aßmus | first8 = Jörg | last9 = Ktoridou-Valen | first9 = Irini | last10 = Mella | first10 = Olav | authorlink10 = Olav Mella | date = 2019-04-02 | title = B-Lymphocyte Depletion in Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial|url=http://annals.org/article.aspx?doi=10.7326/M18-1451|journal=Annals of Internal Medicine|language=en|doi=10.7326/M18-1451|issn=0003-4819}}</ref> - [https://www.clinicaltherapeutics.com/article/S0149-2918(19)30163-8/fulltext (Full text)] *2019, Searching for Serum Antibodies to Neuronal Proteins in Patients With Myalgic Encephalopathy/Chronic Fatigue Syndrome<ref>{{Cite journal | last =Giannoccaro | first = Maria Pia|author-link = | last2 = Cossins | first2=Judith |author-link2 = | last3 = Sørland | first3=Kari | author-link3 = | last4 = Fluge | first4 = Øystein | author-link4 = Øystein Fluge | last5 = Vincent | first5 = Angela | authorlink5 = Angela Vincent | date = May 2019 | title = Searching for Serum Antibodies to Neuronal Proteins in Patients With Myalgic Encephalopathy/Chronic Fatigue Syndrome|url=https://linkinghub.elsevier.com/retrieve/pii/S0149291819301638|journal=Clinical Therapeutics|language=en|volume=41|issue=5 | pages = 836–847|doi=10.1016/j.clinthera.2019.04.001|quote=|via=}}</ref> - [https://www.clinicaltherapeutics.com/article/S0149-2918(19)30163-8/fulltext (Full text)] *2020, Human Leukocyte Antigen alleles associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)<ref name="Asgeir2020">{{Cite journal | last =Lande | first = Asgeir | authorlink = Asgeir Lande | last2 = Fluge | first2 = Øystein | author-link2 = Øystein Fluge | last3 = Strand | first3=Elin B. | author-link3 = Elin Strand | last4 = Flåm | first4 = Siri T. | author-link4 = Siri Flåm | last5 = Sosa | first5 = Daysi D. | authorlink5 = Daysi Sosa|last6 = Mella | first6 = Olav | authorlink6 = Olav Mella | last7 = Egeland | first7 = Torstein | authorlink7 = | last8 = Saugstad | first8 = Ola D. | authorlink8 = | last9 = Lie | first9 = Benedicte A. | authorlink9 = | date = 2020-03-24 | title = Human Leukocyte Antigen alleles associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)|url=https://www.nature.com/articles/s41598-020-62157-x|journal=Scientific Reports|language=en|volume=10|issue=1|pages=1–8|doi=10.1038/s41598-020-62157-x|issn=2045-2322|pmc=|pmid=|access-date=|quote=|via=}}</ref> - [https://www.nature.com/articles/s41598-020-62157-x (Full text)] * 2020, Intravenous Cyclophosphamide in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. An Open-Label Phase II Study<ref name="Rekeland2020">{{Cite journal | last =Rekeland | first=Ingrid G.|author-link = | last2 = Fosså | first2 = Alexander | author-link2 = | last3 = Lande | first3 = Asgeir | author-link3 = | last4 = Ktoridou-Valen | first4=Irini | author-link4 = | last5 = Sørland | first5 = Kari | authorlink5 = |last6 = Holsen | first6 = Mari | author-link6 = | last7 = Tronstad | first7 = Karl J. | authorlink7 = Karl Tronstad | last8 = Risa | first8 = Kristin | authorlink8 = | last9 = Alme | first9 = Kine | authorlink9 = | last10 = Viken | first10 = Marte K. | authorlink10 = | last11 = Lie | first11 = Benedicte K. | authorlink11 = | last12 = Dahl | first12 = Olav | authorlink12 = | last13 = Mella | first13 = Olav | authorlink13 = Olav Mella | first14 = Øystein | last14 = Fluge | author-link14 = Øystein Fluge | date = 2020 | title=Intravenous Cyclophosphamide in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. An Open-Label Phase II Study|url=https://www.frontiersin.org/articles/10.3389/fmed.2020.00162/full|journal=Frontiers in Medicine|language=English|volume=7|issue=|pages=162|pmc=PMC7201056|pmid=32411717|doi=10.3389/fmed.2020.00162|issn=2296-858X|quote=|via=}}</ref> - [https://www.frontiersin.org/articles/10.3389/fmed.2020.00162/full? (Full text)]
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